Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 1891872..1893122 Replicon chromosome
Accession NZ_CP069483
Organism Burkholderia dolosa strain FDAARGOS_1272

Toxin (Protein)


Gene name vapC Uniprot ID A0A892IA44
Locus tag I6K02_RS24185 Protein ID WP_006766297.1
Coordinates 1891872..1892471 (-) Length 200 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A892I3E7
Locus tag I6K02_RS24190 Protein ID WP_035974448.1
Coordinates 1892565..1893122 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K02_RS24165 1886894..1887691 + 798 WP_035974452.1 enoyl-CoA hydratase -
I6K02_RS24170 1887688..1888827 + 1140 WP_006766300.1 enoyl-CoA hydratase/isomerase family protein -
I6K02_RS24175 1888914..1889819 - 906 WP_035974451.1 LysR family transcriptional regulator -
I6K02_RS24180 1889992..1891530 + 1539 WP_006766298.1 MFS transporter -
I6K02_RS24185 1891872..1892471 - 600 WP_006766297.1 HD domain-containing protein Toxin
I6K02_RS24190 1892565..1893122 - 558 WP_035974448.1 helix-turn-helix domain-containing protein Antitoxin
I6K02_RS24195 1893467..1894870 + 1404 WP_006766295.1 hypothetical protein -
I6K02_RS24200 1894986..1896244 + 1259 Protein_1634 IS256 family transposase -
I6K02_RS24205 1896234..1896464 + 231 WP_105773928.1 integrase core domain-containing protein -
I6K02_RS24210 1896742..1896954 - 213 WP_105773927.1 transposase -
I6K02_RS24215 1897245..1897742 + 498 WP_123806756.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-168)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-49)


Sequences

Toxin        


Download         Length: 200 a.a.        Molecular weight: 21892.64 Da        Isoelectric Point: 5.1098

>T190618 WP_006766297.1 NZ_CP069483:c1892471-1891872 [Burkholderia dolosa]
MTPDTIHARLDFLREAERLKDVLRSGRTSSGRAESTAEHSWRLCLMALAFADALPGVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERNDLLTLTAALDGPLRDEIVALWDEYEAVATPEARAAKALDKLETILQHNQGDNPPDFDYAFNLDY
GRRYTDAAPLFIAIRAVVDADTQRRIDARAHTACTKGSA

Download         Length: 600 bp

>T190618 NZ_CP091492:3605622-3605945 [Enterobacter cloacae complex sp. ECL405]
ATGCAAATTTCATCTGTACCGGCCACGGTGCCGGTTTCGTCACGCCTGTCGCCCGTAATGGTGTGGCAGCAGCTGTTAAC
GTATCTACTGGAGCACCACTACGGCCTGACACTCAACGACACACCATTTCATGACGACACGGCCATTCAGGGACATATCG
AGGCGGGGATAACTCTAGCCGATGCGGTTAATTTCCTGGTCGAAAAGTACGAACTCGTTCGTATCGACCGGAAGGGATTT
TCATGGCAAGAGCAAACGCCCTTCATTACCGCAACGGATATTCTGCGTGCCAAAAAGAGCATCGGGCTGTTGCCCAGATC
TTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20283.30 Da        Isoelectric Point: 8.8096

>AT190618 WP_035974448.1 NZ_CP069483:c1893122-1892565 [Burkholderia dolosa]
MAAPALHTPPLGPQLKRWRVLHRIKQSHAAELFGVAQSTISRWEAGIQQMSADERATAERLLAAHLDSAGDHALARLIAD
SAGRMHLVCDLTHRLLACSPLRAAEFSQPLPLLLGTSLWRYATPEIVRMESALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSRCRWTRMTLSDGSAVRLVETL

Download         Length: 558 bp

>AT190618 NZ_CP091492:3605267-3605590 [Enterobacter cloacae complex sp. ECL405]
ATGCAAAATTCATGGGGACTGAAGCGCGACATCTCGCCGTGCTTCGGTGCAAGGCTTGTGCAGGAAGGCTGTCGCCTGCA
TTTTCTGGCGGACCGTGCAGGTATTAGTGGTACGTTTAACGAGGAGGAGGCACTGTGTCTGGATCAGGCATTTCCGCTAG
TGATGAAACAGCTTGAATTGATGCTGACAACCGGTGAACTGAATCCGCGCCATCAGCATTGCGTCACGTTGTATCATAAC
GGACTAACTTGTGAAGCTGACACTCTCGGCTCTCATGGCTATGTTTACATCGTTATTTATCCTCAGGCATTTGCAACCAG
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References