Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/DUF4065(antitoxin) |
| Location | 2159973..2160961 | Replicon | chromosome |
| Accession | NZ_CP069480 | ||
| Organism | Escherichia coli strain FDAARGOS_1257 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | I6J87_RS10530 | Protein ID | WP_014640052.1 |
| Coordinates | 2159973..2160359 (-) | Length | 129 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | A0A0J5Z6D5 |
| Locus tag | I6J87_RS10535 | Protein ID | WP_000458584.1 |
| Coordinates | 2160389..2160961 (-) | Length | 191 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6J87_RS10480 | 2155056..2155880 | + | 825 | WP_000081295.1 | YfdQ family protein | - |
| I6J87_RS10485 | 2156009..2156545 | + | 537 | WP_000008178.1 | 5'-deoxynucleotidase | - |
| I6J87_RS10490 | 2156536..2156955 | + | 420 | WP_021549915.1 | hypothetical protein | - |
| I6J87_RS10495 | 2156952..2157251 | + | 300 | WP_021549914.1 | hypothetical protein | - |
| I6J87_RS10500 | 2157253..2157933 | + | 681 | WP_021549913.1 | ead/Ea22-like family protein | - |
| I6J87_RS10505 | 2157935..2158222 | + | 288 | WP_021549912.1 | hypothetical protein | - |
| I6J87_RS10510 | 2158226..2158822 | + | 597 | WP_021549911.1 | DUF551 domain-containing protein | - |
| I6J87_RS10515 | 2158822..2159394 | + | 573 | WP_021549910.1 | 3'-5' exoribonuclease | - |
| I6J87_RS10520 | 2159431..2159712 | + | 282 | WP_001093919.1 | pyocin activator PrtN family protein | - |
| I6J87_RS10525 | 2159760..2159933 | - | 174 | WP_021549909.1 | hypothetical protein | - |
| I6J87_RS10530 | 2159973..2160359 | - | 387 | WP_014640052.1 | hypothetical protein | Toxin |
| I6J87_RS10535 | 2160389..2160961 | - | 573 | WP_000458584.1 | SocA family protein | Antitoxin |
| I6J87_RS10540 | 2161433..2161948 | + | 516 | WP_000416264.1 | zinc uptake transcriptional repressor Zur | - |
| I6J87_RS10545 | 2161990..2162199 | - | 210 | WP_001296638.1 | CsbD family protein | - |
| I6J87_RS10550 | 2162315..2163640 | - | 1326 | WP_001298291.1 | MATE family efflux transporter DinF | - |
| I6J87_RS10555 | 2163713..2164321 | - | 609 | WP_000646078.1 | transcriptional repressor LexA | - |
| I6J87_RS10560 | 2164431..2164799 | - | 369 | WP_000002899.1 | diacylglycerol kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2107300..2164799 | 57499 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 129 a.a. Molecular weight: 14465.40 Da Isoelectric Point: 5.4833
>T190595 WP_014640052.1 NZ_CP069480:c2160359-2159973 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE
Download Length: 387 bp
>T190595 NZ_CP091481:c3017136-3016804 [Enterobacter cloacae complex sp. ECL414]
ATGGACAGAGGGGAAATTTGGCTCGTCTCACTGGATCCTACAGCCGGACATGAACAAAGCGGAAAACGTCCGGTGCTTAT
CGTATCGAAGGCATCTTTTAACAAGCTGACCCGGTTACCCGTTGTTGTTCCCATCACCAGCGGTGGAAACTTTGCACGTA
CAGCCGGTTTTACCGTCTCCCTGGACGGTGCGGGAACAAAAACGATGGGCGCTATTCGCTGCGACCAGCCCAGAACCATT
GATATGGCTGCCCGGAGCGGCAAGCGGCTGGAACGCATACCAGACGCTGTGGTGAATGAGGTGCTTGCCAGGCTGGATGC
GATTCTGAATTAA
ATGGACAGAGGGGAAATTTGGCTCGTCTCACTGGATCCTACAGCCGGACATGAACAAAGCGGAAAACGTCCGGTGCTTAT
CGTATCGAAGGCATCTTTTAACAAGCTGACCCGGTTACCCGTTGTTGTTCCCATCACCAGCGGTGGAAACTTTGCACGTA
CAGCCGGTTTTACCGTCTCCCTGGACGGTGCGGGAACAAAAACGATGGGCGCTATTCGCTGCGACCAGCCCAGAACCATT
GATATGGCTGCCCGGAGCGGCAAGCGGCTGGAACGCATACCAGACGCTGTGGTGAATGAGGTGCTTGCCAGGCTGGATGC
GATTCTGAATTAA
Antitoxin
Download Length: 191 a.a. Molecular weight: 21973.21 Da Isoelectric Point: 6.0283
>AT190595 WP_000458584.1 NZ_CP069480:c2160961-2160389 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHNVSLRSDPREMDADEVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHNVSLRSDPREMDADEVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS
Download Length: 573 bp
>AT190595 NZ_CP091481:c3017394-3017137 [Enterobacter cloacae complex sp. ECL414]
ATGTATACCACTCGCCTGAAAAAGGTCGGCGGATCCATCATGTTGGCGGTTCCTCCCGCCGTGCTCAAAACACTGGAGCT
GTCGACGGACAGCGAAGTCGGCATGACCATAAATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAACTGCTGGCACAGTGCGATCCGCACGCCGAAATGAGCGACGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATCCTGTAA
ATGTATACCACTCGCCTGAAAAAGGTCGGCGGATCCATCATGTTGGCGGTTCCTCCCGCCGTGCTCAAAACACTGGAGCT
GTCGACGGACAGCGAAGTCGGCATGACCATAAATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAACTGCTGGCACAGTGCGATCCGCACGCCGAAATGAGCGACGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATCCTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|