190579

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1404147..1404676 Replicon chromosome
Accession NZ_CP069473
Organism Staphylococcus epidermidis strain FDAARGOS_1243

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag I6J73_RS06690 Protein ID WP_001829891.1
Coordinates 1404314..1404676 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag I6J73_RS06685 Protein ID WP_001829931.1
Coordinates 1404147..1404317 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J73_RS06660 1399972..1400451 + 480 WP_001829909.1 PH domain-containing protein -
I6J73_RS06665 1400444..1401949 + 1506 WP_001829976.1 PH domain-containing protein -
I6J73_RS06670 1401936..1402445 + 510 WP_001829888.1 PH domain-containing protein -
I6J73_RS06675 1402493..1402846 + 354 WP_001829915.1 holo-ACP synthase -
I6J73_RS06680 1402912..1404060 + 1149 WP_001829972.1 alanine racemase -
I6J73_RS06685 1404147..1404317 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
I6J73_RS06690 1404314..1404676 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6J73_RS06695 1405021..1406022 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
I6J73_RS06700 1406122..1406448 + 327 WP_001829952.1 anti-sigma factor antagonist -
I6J73_RS06705 1406450..1406929 + 480 WP_001829903.1 anti-sigma B factor RsbW -
I6J73_RS06710 1406904..1407674 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T190579 WP_001829891.1 NZ_CP069473:1404314-1404676 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T190579 NZ_CP091470:c65808-65500 [Klebsiella michiganensis]
ATGCAGTATTACGTTTATAAGAATACAGGTCGAATTGCTGCGTATCCTTACCTCCTTGATGTACAGAGTGACATTATCGG
CAAGCGCAATACTCGGGTCGTGATTCCACTGTTTCCACTGAAAAACTATAAAGGTCCACGCGCCGATCGTTTAACACCGC
TTGTCACCGTAGAAGGGGAAGAATACGTCGTGATGACTCACGAACTCGCCAGTATCCCACATCGTGTTCTGGGTGAAGAA
GTTTGTAATCTGAATCACCAGCGCGAAGTCGTTAAAGCTTCAATGGATTTTCTTTTCGACGGGATCTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT190579 WP_001829931.1 NZ_CP069473:1404147-1404317 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT190579 NZ_CP091470:c66047-65811 [Klebsiella michiganensis]
ATGCCAGCCGCAAAACGCAATAAGCAGAACGTCAGCGTGACACTGGACCCAGGCCTGGTCAAACAGGCTCGTGAGGTCGG
CATCAATCTGTCTCTAACGTTGACTAACGCTCTAAAAAGCGAAATCCACAGCCTCGAAATAGCCCGCTGGCAAAAAGAAA
ATGCCCAGGCAATCGACTACCTCAATAATTTAACTGAGGAAAATGGACTTCTCTCTGATGAATACAGGACGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References