190578

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1392964..1393473 Replicon chromosome
Accession NZ_CP069473
Organism Staphylococcus epidermidis strain FDAARGOS_1243

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag I6J73_RS06630 Protein ID WP_001829980.1
Coordinates 1393264..1393473 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag I6J73_RS06625 Protein ID WP_001829893.1
Coordinates 1392964..1393257 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J73_RS06600 1387972..1388760 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
I6J73_RS06605 1388766..1389404 + 639 WP_002505076.1 thiamine phosphate synthase -
I6J73_RS06610 1389493..1390365 + 873 WP_001832740.1 membrane protein insertase YidC -
I6J73_RS06615 1390471..1391124 - 654 WP_001829983.1 HD domain-containing protein -
I6J73_RS06620 1391306..1392790 - 1485 WP_001829964.1 cardiolipin synthase -
I6J73_RS06625 1392964..1393257 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6J73_RS06630 1393264..1393473 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
I6J73_RS06635 1393616..1393753 + 138 WP_001829949.1 hypothetical protein -
I6J73_RS06640 1393853..1395064 - 1212 WP_001829910.1 rod shape-determining protein RodA -
I6J73_RS06645 1395455..1396528 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
I6J73_RS06650 1396540..1397895 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T190578 WP_001829980.1 NZ_CP069473:1393264-1393473 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T190578 NZ_CP091470:40279-40620 [Klebsiella michiganensis]
ATGTGGGATGTTGAAACAACGGAGGTTTTTGACAAGTGGTTTGAGGCGCAGACCGAAGCGCTCAAAGAGGATATGCTCGC
CGCAATGGTGATCTTATCCGAGTATGGCCCCCGGTTGGGAAGGCCGTTTGCGGATACAGTAAACGATTCTGCCTTTTCGA
ATATGAAAGAGCTGCGCATTCAGCATCAAGGTAGACCCATCCGAGCTTTCTTTGTATTTGACCCTTCTCGTTGTGGCATC
GTGTTATGCGCCGGAGATAAAACAGGGTTAAATGAAAAGAGATTCTATAAAGATATGATCAAGCTTGCAGATGCTGAGTA
CCGTAAGCACCTTAATCAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT190578 WP_001829893.1 NZ_CP069473:1392964-1393257 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT190578 NZ_CP091470:40630-40929 [Klebsiella michiganensis]
ATGGCGACCCTTAAAGAATTAATGGCCAAACAGAGCCCGGAAAGCCAGGCGCGTATTGCTGAAAAAGTCGAGGAGATGCG
CCAGGCTATCGCTTTAAGTATGTTAAGGGAAGAACTCAATATGTCTCAGGCAGAGCTGGCTAAGGCAATGGGCGTTAAAC
AACCCACCATAGCAAAAATGGAACAGGCTGATAACGACCCGCGTTTGTCAACGCTGAAGCGCTATGTTGCAGCGCTCGGG
GGGGAACTCAGTATTGATGTTAAGCTGCCAACCGGTAAGCGAATCGCATTCCATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References