190577

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2014075..2014552 Replicon chromosome
Accession NZ_CP069470
Organism Staphylococcus aureus strain FDAARGOS_1246

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag I6J76_RS10260 Protein ID WP_000052078.1
Coordinates 2014364..2014552 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag I6J76_RS10255 Protein ID WP_001059690.1
Coordinates 2014075..2014335 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J76_RS10220 2009468..2010184 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
I6J76_RS10225 2010332..2010754 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
I6J76_RS10230 2011153..2011647 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
I6J76_RS10235 2011802..2012419 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
I6J76_RS10240 2012492..2013073 - 582 WP_001140686.1 phosphoglycerate mutase family protein -
I6J76_RS10245 2013298..2013534 + 237 WP_000368687.1 hypothetical protein -
I6J76_RS10250 2013531..2013734 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
I6J76_RS10255 2014075..2014335 + 261 WP_001059690.1 hypothetical protein Antitoxin
I6J76_RS10260 2014364..2014552 + 189 WP_000052078.1 hypothetical protein Toxin
I6J76_RS10265 2014740..2015309 + 570 WP_001106654.1 hypothetical protein -
I6J76_RS10270 2015397..2015681 + 285 WP_001004395.1 hypothetical protein -
I6J76_RS10275 2015743..2015961 + 219 WP_000005886.1 hypothetical protein -
I6J76_RS10280 2016457..2016657 - 201 WP_001059082.1 cold-shock protein -
I6J76_RS10285 2017014..2017700 - 687 WP_001548082.1 thermonuclease family protein -
I6J76_RS10290 2018041..2018511 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T190577 WP_000052078.1 NZ_CP069470:2014364-2014552 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T190577 NZ_CP091468:c2856339-2855989 [Weizmannia coagulans]
TTGATTGTTAAGCGTGGAGACGTGTACTTCGCCGATCTATCTCCGGTGGTCGGCTCCGAGCAGGGAGGCGTACGTCCTGT
CCTCATTTTACAAAACGACATTGGAAACCGTTTTAGCCCCACTGTCATTGTTGCCGCTATAACAGCGCAAATCCAGAAAG
CAAAATTGCCCACGCATGTGGAAATTGATGCAAAGCGTTACGGTTTGGAAAGGGATTCTGTGATATTGCTTGAACAAATA
CGCACAATCGATAAACAACGCTTAACGGATAAGATTACGCATCTTGATGAAGAAGTCATGGAGAAAATTGACGACGCCCT
GCAAATCAGCCTGGGACTGGTCGAATTTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT190577 WP_001059690.1 NZ_CP069470:2014075-2014335 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT190577 NZ_CP091468:c2856622-2856344 [Weizmannia coagulans]
GTGTCTGAACCTATTTCAACAGAAATTTTAGTCCGCTTGCCGCAGCAGCTGTTGACGGAATTGGACGGATTTGCTGAAAC
TGAAAATATGAATCGCAATGAATTAATTTACCGTGCCACAAAAATGTATTTAAAAGAACGGAAAAAACGCCAAATCCGCG
AAACGATGAGGCGTGGTTACATGGAAATGGCAAAAATTAATTTGGCGATTGCCTCCGAAGCGATCCAGGCTGAATACGAA
GCAGAACATACAGTTGAAAGCCTAGTAAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References