Detailed information of TA system TA190574

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 909373..910149
• Replicon: chromosome
• Accession: NZ_CP069470
• Organism: Staphylococcus aureus strain FDAARGOS_1246

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: I6J76_RS04810
• Protein ID: WP_000031108.1
• Coordinates: 909997..910149 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: I6J76_RS04805
• Protein ID: WP_001251224.1
• Coordinates: 909373..909972 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J76_RS04785	905289..906746	+	1458	WP_000649907.1	ABC transporter permease subunit	-
I6J76_RS04790	906739..907461	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
I6J76_RS04795	907612..908739	+	1128	WP_000379978.1	tRNA epoxyqueuosine(34) reductase QueG	-
I6J76_RS04800	908744..909214	+	471	WP_000181398.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
I6J76_RS04805	909373..909972	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
I6J76_RS04810	909997..910149	+	153	WP_000031108.1	hypothetical protein	Toxin
I6J76_RS04815	910926..911321	+	396	WP_000901021.1	hypothetical protein	-
I6J76_RS04820	911517..912902	+	1386	WP_000116224.1	class II fumarate hydratase	-
I6J76_RS04825	913365..914186	-	822	WP_000669376.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T190574 WP_000031108.1 NZ_CP069470:909997-910149 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T190574 NZ_CP091456:c2337821-2337459 [Avibacterium sp. 20-132]
ATGAAACAAGAATGGGAAGTTATTTTACAAGACCCGCTTTTAAGTTGGTTTGATACGTTGGCAGAAGATGATTTATTAAA
AGTCTATGCTGCATTGGAATTATTATCAACAGAAGGTCCGCAATTAGGTAGACCGTATGCTGATACACTACAAGGTTCTA
AATATACCAATTTAAAAGAATTGAGAGTGCAGTCTAAATTATCCGTATTTCGTTTGTTTTATCTCTTTGATCCAATTCGA
CAAGCTATTGTGTTATGTGGTGGAGATAAAAAGGGCAAAAAAGAGAAACTCTTTTACAAAGAGATGATCGCACTTGCCGA
GAAAACTTACGAGGATTACCTTTCTGAATTTTCAAAGGAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT190574 WP_001251224.1 NZ_CP069470:909373-909972 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT190574 NZ_CP091456:c2337454-2337152 [Avibacterium sp. 20-132]
ATGAGCGTAGCATTTAAAGATTTAATGAGTAAACTTCCTGCTGAAAAGCAAGCGAAAGTGAAAGCAATGGCTGATGATAT
GCGTATGGAGTTACAACTTTACCGCATTCGTGAAGAATTAGAACTTTCACAAAAACAAATGGCGGAAGCGTTAAATATTT
CTCAGCCATCTGTTGTTGCACTTGAAAAACGTGGTAATGATATTAAATTATCATCAGTTAAGCGATATATTGAAGCAATG
GGCGGTGTTTTAAATTTATCGGTTGAATTACCTACTGGGAAAACCGTCACCTTTAATTTATAA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4