190569

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 689195..689709 Replicon chromosome
Accession NZ_CP069470
Organism Staphylococcus aureus strain FDAARGOS_1246

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag I6J76_RS03450 Protein ID WP_000581792.1
Coordinates 689500..689709 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag I6J76_RS03445 Protein ID WP_000138932.1
Coordinates 689195..689488 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J76_RS03425 684458..685099 + 642 WP_000483153.1 thiamine phosphate synthase -
I6J76_RS03430 685185..686057 + 873 WP_000725802.1 membrane protein insertase YidC -
I6J76_RS03435 686870..687517 - 648 WP_001187629.1 HD domain-containing protein -
I6J76_RS03440 687545..689029 - 1485 WP_000571549.1 cardiolipin synthase -
I6J76_RS03445 689195..689488 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6J76_RS03450 689500..689709 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
I6J76_RS03455 689837..689974 + 138 WP_000828354.1 hypothetical protein -
I6J76_RS03460 690238..691440 - 1203 WP_001109939.1 rod shape-determining protein RodA -
I6J76_RS03465 691758..692828 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
I6J76_RS03470 692843..694201 + 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T190569 WP_000581792.1 NZ_CP069470:689500-689709 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T190569 NZ_CP091456:c2138240-2137881 [Avibacterium sp. 20-132]
ATGACTAAACCACAGCACTGGAACGTTATATTAACGGATAATTTTGTTGCTTGGTTGAAACAGCAAAACAATGCTATTCA
AGAAGATGTTACCGCTGCACTTTTACTTTTAAAAACGGTTGGCCCCGAACTTTCTCGTCCTTATGCCGATACGCTGAAAG
GTTCGCAATACCCAAATATGAAAGAGCTACGCATTCAACATCAAGGCAAGCCCTTAAGAGCACTTTTTGCTTTTGATCCC
TTGCGTCAAGCTATTATTTTATGTGCAGGTGATAAAAGCAACGATAAACAGTTCTATAAGAGAATGATCAAACAAGCTGA
CGCTGAATTTAGCGCTTATTTAAGAACACTGGAGAAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT190569 WP_000138932.1 NZ_CP069470:689195-689488 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT190569 NZ_CP091456:c2137879-2137580 [Avibacterium sp. 20-132]
ATGAAAACTTTAGAACAACTTTTAGATGAGTTTTCTCCTGAAGCTCGCCAAAGAATTGAGCAAAAAGCAGAAGAATTACT
GCTTGAGTCAGGATTATCTAGCATTCGTCAAGAAATGGAAATCTCTCAAAAACAGCTGGCCGATGCCCTTGGTATTTCAC
AACCTGCTGTTGCACAAATCGAACAGCGAGGCAATGAATTACGCCTTTCTACGCTTAAACGCTATGTAGAGACAATGGGC
GGAAAACTCAGCCTTGCTATTGATATGCCTATGGGAGAAACTCGGATTTTTAAAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References