Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 772138..772776 Replicon chromosome
Accession NZ_CP069459
Organism Escherichia coli strain FDAARGOS_1249

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag I6J79_RS03650 Protein ID WP_000813794.1
Coordinates 772138..772314 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag I6J79_RS03655 Protein ID WP_001270286.1
Coordinates 772360..772776 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J79_RS03630 767757..768971 - 1215 WP_001326689.1 BenE family transporter YdcO -
I6J79_RS03635 769024..769560 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
I6J79_RS03640 769633..771594 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
I6J79_RS03645 771686..771916 - 231 WP_000494244.1 YncJ family protein -
I6J79_RS03650 772138..772314 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
I6J79_RS03655 772360..772776 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
I6J79_RS03660 772855..774261 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
I6J79_RS03665 774506..775651 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
I6J79_RS03670 775669..776682 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
I6J79_RS03675 776683..777623 + 941 Protein_725 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T190536 WP_000813794.1 NZ_CP069459:772138-772314 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T190536 NZ_CP091427:c1103020-1102802 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT190536 WP_001270286.1 NZ_CP069459:772360-772776 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT190536 NZ_CP091427:c1103420-1103046 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References