Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 21327..21928 Replicon plasmid unnamed2
Accession NZ_CP069455
Organism Escherichia coli strain FDAARGOS_1254

Toxin (Protein)


Gene name doc Uniprot ID V0AJ64
Locus tag I6J84_RS23110 Protein ID WP_001216034.1
Coordinates 21327..21707 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag I6J84_RS23115 Protein ID WP_001190712.1
Coordinates 21707..21928 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J84_RS23075 16378..17310 - 933 WP_000081352.1 homocysteine S-methyltransferase -
I6J84_RS23080 17297..18700 - 1404 WP_001373486.1 S-methylmethionine permease -
I6J84_RS23085 18908..19924 + 1017 WP_012372828.1 IS5-like element IS5 family transposase -
I6J84_RS23090 20152..20469 + 318 WP_001513659.1 hypothetical protein -
I6J84_RS23095 20419..20832 - 414 Protein_21 DDE-type integrase/transposase/recombinase -
I6J84_RS23100 20756..21115 - 360 WP_001513660.1 hypothetical protein -
I6J84_RS23105 21143..21322 - 180 WP_001513661.1 hypothetical protein -
I6J84_RS23110 21327..21707 - 381 WP_001216034.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
I6J84_RS23115 21707..21928 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I6J84_RS23120 22111..23667 + 1557 WP_001617892.1 type I restriction-modification system subunit M -
I6J84_RS23125 23664..24947 + 1284 WP_001617890.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..34826 34826


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13615.32 Da        Isoelectric Point: 5.1514

>T190524 WP_001216034.1 NZ_CP069455:c21707-21327 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

>T190524 NZ_CP091423:c1976598-1976269 [Streptococcus suis]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTAGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT190524 WP_001190712.1 NZ_CP069455:c21928-21707 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT190524 NZ_CP091423:c1976875-1976588 [Streptococcus suis]
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0AJ64

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References