Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2819715..2820333 Replicon chromosome
Accession NZ_CP069453
Organism Escherichia coli strain FDAARGOS_1254

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag I6J84_RS13150 Protein ID WP_001291435.1
Coordinates 2819715..2819933 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag I6J84_RS13155 Protein ID WP_000344800.1
Coordinates 2819959..2820333 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J84_RS13115 2815003..2815575 + 573 WP_000779831.1 YbaY family lipoprotein -
I6J84_RS13120 2815606..2815917 - 312 WP_000409908.1 MGMT family protein -
I6J84_RS13130 2816296..2816649 + 354 WP_000878140.1 DUF1428 domain-containing protein -
I6J84_RS13135 2816691..2818241 - 1551 WP_001441899.1 cyclic-guanylate-specific phosphodiesterase PdeB -
I6J84_RS13140 2818405..2818875 - 471 WP_000136192.1 YlaC family protein -
I6J84_RS13145 2818991..2819542 - 552 WP_000102539.1 maltose O-acetyltransferase -
I6J84_RS13150 2819715..2819933 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
I6J84_RS13155 2819959..2820333 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
I6J84_RS13160 2820878..2824027 - 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
I6J84_RS13165 2824050..2825243 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T190505 WP_001291435.1 NZ_CP069453:c2819933-2819715 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T190505 NZ_CP091412:69173-69280 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT190505 WP_000344800.1 NZ_CP069453:c2820333-2819959 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT190505 NZ_CP091412:c69357-69297 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References