Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2162782..2163304 Replicon chromosome
Accession NZ_CP069453
Organism Escherichia coli strain FDAARGOS_1254

Toxin (Protein)


Gene name relE Uniprot ID V0VCV4
Locus tag I6J84_RS10125 Protein ID WP_001105537.1
Coordinates 2163014..2163304 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag I6J84_RS10120 Protein ID WP_000212715.1
Coordinates 2162782..2163024 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J84_RS10100 2158493..2159866 + 1374 WP_001219792.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
I6J84_RS10105 2160024..2160575 - 552 WP_000166276.1 ribosome-associated protein -
I6J84_RS10110 2160669..2162021 + 1353 WP_001162187.1 metalloprotease PmbA -
I6J84_RS10115 2162204..2162590 + 387 WP_001232246.1 cytochrome b562 -
I6J84_RS10120 2162782..2163024 + 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6J84_RS10125 2163014..2163304 + 291 WP_001105537.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6J84_RS10130 2163305..2163769 - 465 WP_001106233.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6J84_RS10135 2163927..2166065 - 2139 WP_000187799.1 anaerobic ribonucleoside-triphosphate reductase -
I6J84_RS10140 2166459..2168114 - 1656 WP_001338059.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11383.19 Da        Isoelectric Point: 9.8531

>T190500 WP_001105537.1 NZ_CP069453:2163014-2163304 [Escherichia coli]
MNYELTFDPRALKEWQKLGVTVREQFKKKLEDALKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDADKRLDE

Download         Length: 291 bp

>T190500 NZ_CP091377:c898716-898327 [Acinetobacter baumannii]
TTGCTCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATAAGCTTTATTTTCTTTT
TAAAGCGTCCGCAACTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT190500 WP_000212715.1 NZ_CP069453:2162782-2163024 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT190500 NZ_CP091377:c898980-898723 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0VCV4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References