Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1383496..1384331 Replicon chromosome
Accession NZ_CP069451
Organism Escherichia coli strain FDAARGOS_1256

Toxin (Protein)


Gene name yeeV Uniprot ID Q83W73
Locus tag I6J86_RS06505 Protein ID WP_000854700.1
Coordinates 1383954..1384331 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag I6J86_RS06500 Protein ID WP_001278232.1
Coordinates 1383496..1383864 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J86_RS06480 1381156..1381974 + 819 WP_001234709.1 DUF945 domain-containing protein -
I6J86_RS06485 1382066..1382551 + 486 WP_000213723.1 antirestriction protein -
I6J86_RS06490 1382567..1383043 + 477 WP_001186199.1 RadC family protein -
I6J86_RS06495 1383112..1383333 + 222 WP_000692353.1 DUF987 domain-containing protein -
I6J86_RS06500 1383496..1383864 + 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
I6J86_RS06505 1383954..1384331 + 378 WP_000854700.1 TA system toxin CbtA family protein Toxin
I6J86_RS06510 1384328..1384816 + 489 WP_000761726.1 hypothetical protein -
I6J86_RS06515 1384828..1385025 + 198 WP_000839247.1 DUF957 domain-containing protein -
I6J86_RS06520 1385110..1385964 + 855 WP_024174313.1 DUF4942 domain-containing protein -
I6J86_RS06525 1386057..1387376 - 1320 WP_000144686.1 site-specific integrase -
I6J86_RS06530 1387742..1388080 + 339 WP_000772639.1 Arm DNA-binding domain-containing protein -
I6J86_RS06535 1388515..1389009 - 495 WP_001059463.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - vat / yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC 1357763..1433310 75547


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14276.28 Da        Isoelectric Point: 7.8046

>T190470 WP_000854700.1 NZ_CP069451:1383954-1384331 [Escherichia coli]
MKTLPDTHVREASRCLSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SPCTRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T190470 NZ_CP091361:957430-957732 [Acinetobacter baumannii]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAGCAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCGGTCGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGGCCAGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTTGTTATTCTTTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT190470 WP_001278232.1 NZ_CP069451:1383496-1383864 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT190470 NZ_CP091361:957733-958014 [Acinetobacter baumannii]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAGGATGATATGCAGGCTTACTTACAAGCATG
TATTGAAGAATCTAATGGCGATGCCGCATTCATTGCAAAGGCTTTAGGTAACATTGCAAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGCTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A1I2

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References