Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1069305..1069855 Replicon chromosome
Accession NZ_CP069451
Organism Escherichia coli strain FDAARGOS_1256

Toxin (Protein)


Gene name ccdB Uniprot ID S1PDG4
Locus tag I6J86_RS05055 Protein ID WP_001160966.1
Coordinates 1069541..1069855 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1NMQ0
Locus tag I6J86_RS05050 Protein ID WP_000125568.1
Coordinates 1069305..1069538 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J86_RS05025 1064378..1064665 + 288 WP_000203741.1 ferredoxin-like protein FixX -
I6J86_RS05030 1064724..1066055 + 1332 WP_001183198.1 MFS transporter -
I6J86_RS05035 1066163..1066693 + 531 WP_000600732.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
I6J86_RS05040 1066686..1068548 + 1863 WP_000377109.1 glutathione-regulated potassium-efflux system protein KefC -
I6J86_RS05045 1068740..1069219 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
I6J86_RS05050 1069305..1069538 + 234 WP_000125568.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
I6J86_RS05055 1069541..1069855 + 315 WP_001160966.1 CcdB family protein Toxin
I6J86_RS05060 1069852..1070700 - 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
I6J86_RS05065 1070707..1071084 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
I6J86_RS05070 1071087..1071908 - 822 WP_001065363.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
I6J86_RS05075 1071905..1072894 - 990 WP_000241225.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
I6J86_RS05080 1072894..1074180 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.72 Da        Isoelectric Point: 9.0851

>T190468 WP_001160966.1 NZ_CP069451:1069541-1069855 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T190468 NZ_CP091361:60267-60449 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8560.55 Da        Isoelectric Point: 5.8062

>AT190468 WP_000125568.1 NZ_CP069451:1069305-1069538 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENTEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT190468 NZ_CP091361:60542-60946 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G815

Antitoxin

Source ID Structure
AlphaFold DB A0A829GEF2

References