Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 868712..869547 Replicon chromosome
Accession NZ_CP069451
Organism Escherichia coli strain FDAARGOS_1256

Toxin (Protein)


Gene name yeeV Uniprot ID Q1R2L4
Locus tag I6J86_RS04030 Protein ID WP_001094426.1
Coordinates 869170..869547 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q1R2L5
Locus tag I6J86_RS04025 Protein ID WP_001285575.1
Coordinates 868712..869080 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J86_RS03990 864605..865285 + 681 WP_001282919.1 WYL domain-containing protein -
I6J86_RS03995 865433..866110 + 678 WP_001097301.1 hypothetical protein -
I6J86_RS04000 866116..866349 + 234 WP_001278290.1 DUF905 family protein -
I6J86_RS04005 866439..867257 + 819 WP_001175160.1 DUF945 domain-containing protein -
I6J86_RS04010 867348..867833 + 486 WP_000213697.1 antirestriction protein -
I6J86_RS04015 867848..868324 + 477 WP_001298074.1 RadC family protein -
I6J86_RS04020 868411..868632 + 222 WP_000692350.1 DUF987 domain-containing protein -
I6J86_RS04025 868712..869080 + 369 WP_001285575.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6J86_RS04030 869170..869547 + 378 WP_001094426.1 TA system toxin CbtA family protein Toxin
I6J86_RS04035 869544..870032 + 489 WP_000761683.1 hypothetical protein -
I6J86_RS04040 870044..870241 + 198 WP_000839272.1 DUF957 domain-containing protein -
I6J86_RS04045 870320..870478 + 159 WP_001467148.1 hypothetical protein -
I6J86_RS04050 871430..873466 + 2037 WP_000417001.1 hypothetical protein -
I6J86_RS04055 873865..874044 - 180 WP_001298063.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14072.99 Da        Isoelectric Point: 7.3523

>T190461 WP_001094426.1 NZ_CP069451:869170-869547 [Escherichia coli]
MNTLPDTHIREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T190461 NZ_CP091357:3082742-3083131 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13709.52 Da        Isoelectric Point: 6.6258

>AT190461 WP_001285575.1 NZ_CP069451:868712-869080 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT190461 NZ_CP091357:3082478-3082735 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454ABD6

Antitoxin

Source ID Structure
AlphaFold DB A0A454ABF5

References