Detailed information of TA system TA190455

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4546783..4547603
• Replicon: chromosome
• Accession: NZ_CP069447
• Organism: Escherichia coli strain FDAARGOS_1255

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: I6J85_RS21640
• Protein ID: WP_001054379.1
• Coordinates: 4546783..4547040 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: I6J85_RS21645
• Protein ID: WP_000123957.1
• Coordinates: 4547052..4547603 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J85_RS21620	4542330..4543310	+	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
I6J85_RS21625	4543893..4544999	-	1107	Protein_4217	DNA helicase	-
I6J85_RS21630	4545062..4546209	+	1148	WP_085949154.1	IS3-like element ISEc52 family transposase	-
I6J85_RS21635	4546242..4546406	+	165	Protein_4219	GNAT family N-acetyltransferase	-
I6J85_RS21640	4546783..4547040	+	258	WP_001054379.1	YjhX family toxin	Toxin
I6J85_RS21645	4547052..4547603	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
I6J85_RS21650	4547655..4548401	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
I6J85_RS21655	4548529..4548789	+	261	WP_000077645.1	hypothetical protein	-
I6J85_RS21660	4548827..4548943	+	117	Protein_4224	VOC family protein	-
I6J85_RS21665	4549188..4550309	+	1122	WP_000010833.1	M42 family metallopeptidase	-
I6J85_RS21670	4550306..4550584	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
I6J85_RS21675	4550596..4551909	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimE	4535401..4555824	20423

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T190455 WP_001054379.1 NZ_CP069447:4546783-4547040 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T190455 NZ_CP091356:c9218-9036 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT190455 WP_000123957.1 NZ_CP069447:4547052-4547603 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT190455 NZ_CP091356:c8943-8539 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: B6I030