Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1195294..1196128 Replicon chromosome
Accession NZ_CP069447
Organism Escherichia coli strain FDAARGOS_1255

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2VDB0
Locus tag I6J85_RS05715 Protein ID WP_000854688.1
Coordinates 1195294..1195671 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0H2VAY1
Locus tag I6J85_RS05720 Protein ID WP_001285596.1
Coordinates 1195748..1196128 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J85_RS05685 1190842..1191776 - 935 Protein_1100 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
I6J85_RS05690 1191769..1192164 - 396 WP_000208383.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
I6J85_RS05695 1192233..1193078 - 846 WP_001280441.1 DUF4942 domain-containing protein -
I6J85_RS05700 1193362..1194381 - 1020 WP_000875213.1 IS110 family transposase -
I6J85_RS05705 1194595..1194792 - 198 WP_000839260.1 DUF957 domain-containing protein -
I6J85_RS05710 1194809..1195297 - 489 WP_000761701.1 hypothetical protein -
I6J85_RS05715 1195294..1195671 - 378 WP_000854688.1 TA system toxin CbtA family protein Toxin
I6J85_RS05720 1195748..1196128 - 381 WP_001285596.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6J85_RS05725 1196178..1196822 - 645 WP_000094917.1 hypothetical protein -
I6J85_RS05730 1196841..1197062 - 222 WP_000692329.1 DUF987 domain-containing protein -
I6J85_RS05735 1197125..1197601 - 477 WP_001186726.1 RadC family protein -
I6J85_RS05740 1197617..1198102 - 486 WP_000849564.1 antirestriction protein -
I6J85_RS05745 1198157..1198975 - 819 WP_001234616.1 DUF945 domain-containing protein -
I6J85_RS05750 1199076..1199309 - 234 WP_001119727.1 DUF905 family protein -
I6J85_RS05755 1199388..1199843 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - kpsM / kpsT / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF 1172244..1198102 25858
- flank IS/Tn - - 1193362..1194381 1019


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14014.01 Da        Isoelectric Point: 8.5221

>T190434 WP_000854688.1 NZ_CP069447:c1195671-1195294 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T190434 NZ_CP091343:c1916140-1915958 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATAGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACGT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13897.70 Da        Isoelectric Point: 4.7959

>AT190434 WP_001285596.1 NZ_CP069447:c1196128-1195748 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCAVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT190434 NZ_CP091343:c1915865-1915461 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2VDB0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2VAY1

References