Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3949550..3950348 Replicon chromosome
Accession NZ_CP069445
Organism Escherichia coli strain FDAARGOS_1251

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag I6J81_RS18715 Protein ID WP_001609485.1
Coordinates 3949550..3949927 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag I6J81_RS18720 Protein ID WP_001609483.1
Coordinates 3949974..3950348 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J81_RS18695 3946310..3947845 - 1536 WP_001609560.1 EAL domain-containing protein -
I6J81_RS18700 3947916..3948760 - 845 Protein_3657 DUF4942 domain-containing protein -
I6J81_RS18705 3948856..3949053 - 198 WP_001609487.1 DUF957 domain-containing protein -
I6J81_RS18710 3949065..3949553 - 489 WP_001609486.1 hypothetical protein -
I6J81_RS18715 3949550..3949927 - 378 WP_001609485.1 TA system toxin CbtA family protein Toxin
I6J81_RS18720 3949974..3950348 - 375 WP_001609483.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6J81_RS18725 3950398..3951042 - 645 WP_001609482.1 hypothetical protein -
I6J81_RS18730 3951061..3951282 - 222 WP_001609480.1 DUF987 domain-containing protein -
I6J81_RS18735 3951351..3951827 - 477 WP_001186188.1 RadC family protein -
I6J81_RS18740 3951843..3952322 - 480 WP_001609479.1 antirestriction protein -
I6J81_RS18745 3952404..3953222 - 819 WP_001609564.1 DUF945 domain-containing protein -
I6J81_RS18750 3953321..3953632 - 312 WP_001608658.1 hypothetical protein -
I6J81_RS18755 3953971..3954249 - 279 WP_001545361.1 hypothetical protein -
I6J81_RS18760 3954510..3955190 - 681 WP_001608660.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14276.23 Da        Isoelectric Point: 7.2141

>T190423 WP_001609485.1 NZ_CP069445:c3949927-3949550 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKYPEAKQ

Download         Length: 378 bp

>T190423 NZ_CP091334:c2034379-2033990 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13675.54 Da        Isoelectric Point: 6.4603

>AT190423 WP_001609483.1 NZ_CP069445:c3950348-3949974 [Escherichia coli]
VSDTLPGTTLPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQAFPLLMKQLKLMLTSG
ELNPCHQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTLAPATTS

Download         Length: 375 bp

>AT190423 NZ_CP091334:c2034643-2034386 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCATTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References