Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 372054..372849 Replicon chromosome
Accession NZ_CP069445
Organism Escherichia coli strain FDAARGOS_1251

Toxin (Protein)


Gene name yeeV Uniprot ID Q1RDD2
Locus tag I6J81_RS01745 Protein ID WP_001094434.1
Coordinates 372475..372849 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag I6J81_RS01740 Protein ID WP_001285482.1
Coordinates 372054..372428 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J81_RS01715 368934..369755 + 822 WP_001234582.1 DUF945 domain-containing protein -
I6J81_RS01720 370092..370565 + 474 WP_001313575.1 antirestriction protein -
I6J81_RS01725 370581..371057 + 477 WP_001313574.1 RadC family protein -
I6J81_RS01730 371120..371341 + 222 WP_000692315.1 DUF987 domain-containing protein -
I6J81_RS01735 371360..372004 + 645 WP_000086762.1 hypothetical protein -
I6J81_RS01740 372054..372428 + 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6J81_RS01745 372475..372849 + 375 WP_001094434.1 TA system toxin CbtA family protein Toxin
I6J81_RS01750 372846..373337 + 492 WP_000976859.1 hypothetical protein -
I6J81_RS01755 373349..373546 + 198 WP_000839257.1 DUF957 domain-containing protein -
I6J81_RS01760 373639..374481 + 843 WP_001280460.1 DUF4942 domain-containing protein -
I6J81_RS01770 374952..375890 + 939 WP_000351277.1 glyoxylate/hydroxypyruvate reductase GhrA -
I6J81_RS01775 375945..376682 + 738 WP_000283656.1 zinc-binding phosphatase -
I6J81_RS01780 376706..377260 + 555 WP_001001913.1 molecular chaperone YcdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13921.82 Da        Isoelectric Point: 6.8517

>T190404 WP_001094434.1 NZ_CP069445:372475-372849 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T190404 NZ_CP091329:c5999-5712 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGATATACTAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT190404 WP_001285482.1 NZ_CP069445:372054-372428 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT190404 NZ_CP091329:c5725-5411 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q1RDD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References