190403

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1127148..1127713 Replicon chromosome
Accession NZ_CP069444
Organism [Clostridium] scindens strain FDAARGOS_1227

Toxin (Protein)


Gene name relE Uniprot ID B0NE10
Locus tag I6J57_RS05785 Protein ID WP_004606924.1
Coordinates 1127148..1127438 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A844F6Y3
Locus tag I6J57_RS05790 Protein ID WP_039909695.1
Coordinates 1127435..1127713 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J57_RS05750 1122546..1123232 + 687 Protein_1131 response regulator transcription factor -
I6J57_RS05755 1123229..1124092 + 864 WP_004606931.1 HAMP domain-containing histidine kinase -
I6J57_RS05760 1124203..1124733 + 531 WP_004606930.1 ABC transporter ATP-binding protein -
I6J57_RS05765 1125021..1125467 + 447 WP_004606929.1 hypothetical protein -
I6J57_RS05770 1125472..1125852 + 381 WP_004606928.1 sigma-70 family RNA polymerase sigma factor -
I6J57_RS05775 1125881..1126018 + 138 WP_004606927.1 hypothetical protein -
I6J57_RS05780 1125982..1127040 + 1059 Protein_1137 MobA/MobL family protein -
I6J57_RS05785 1127148..1127438 - 291 WP_004606924.1 type II toxin-antitoxin system YafQ family toxin Toxin
I6J57_RS05790 1127435..1127713 - 279 WP_039909695.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6J57_RS05795 1127824..1127985 + 162 WP_004606922.1 hypothetical protein -
I6J57_RS05800 1127966..1128364 + 399 WP_039909694.1 cysteine-rich VLP domain-containing protein -
I6J57_RS05805 1128478..1128954 + 477 Protein_1142 phage replisome organizer N-terminal domain-containing protein -
I6J57_RS05810 1128955..1129596 + 642 WP_174722024.1 CHAP domain-containing protein -
I6J57_RS05815 1129737..1130444 + 708 WP_004606919.1 LytTR family DNA-binding domain-containing protein -
I6J57_RS05820 1130441..1131727 + 1287 WP_050755140.1 sensor histidine kinase -
I6J57_RS05825 1131904..1132590 + 687 WP_004606917.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-73)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11154.91 Da        Isoelectric Point: 8.0644

>T190403 WP_004606924.1 NZ_CP069444:c1127438-1127148 [[Clostridium] scindens]
MRETKYTVKYTTSFKKDYKRAIKRGLKIELLEQIVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK

Download         Length: 291 bp

>T190403 NZ_CP091329:927-1283 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAATGAATGGCTTGAACAGCAAGATGAAGCAACACAAGAGAAAGTCTTAGC
TGCATTGGTTGTTCTACAACAGCAAGGGCCTAGTTTAGGTCGTCCTTTAGTAGATACCGTCTACGATTCTAAATTTACCA
ATATGAAGGAACTACGTGTTCAGCATCGTGGTAAACCGTTAAGGGCATTTTTTGCATTCGATCCCCTAAGACAAGCGATT
GTGCTGTGTATTGGTGATAAGAGTAATAAAAAGCGTTTTTATACAGAGATGCTAGCAATTGCAGATGAGCAATACGCACT
TCATCTCTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10233.64 Da        Isoelectric Point: 4.4692

>AT190403 WP_039909695.1 NZ_CP069444:c1127713-1127435 [[Clostridium] scindens]
MAGNTTNISIRMDADLKAQADALFSELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR

Download         Length: 279 bp

>AT190403 NZ_CP091329:1276-1578 [Acinetobacter baumannii]
ATGGCTAAGAGCTTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTTTTAGAAAGTCAGCTTCACCTTATCCGAGAAGAGTTAGAAATTTCCCAGAAAGAACTAGCTGCAACCCTTGGAATTA
AACAGCCGTCATTATCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGTGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGGTTCAATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A844F3U5

Antitoxin

Source ID Structure
AlphaFold DB A0A844F6Y3

References