Detailed information of TA system TA190394

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3055186..3055984
• Replicon: chromosome
• Accession: NZ_CP069441
• Organism: Escherichia coli strain FDAARGOS_1261

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: I6J91_RS14365
• Protein ID: WP_001609485.1
• Coordinates: 3055186..3055563 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: I6J91_RS14370
• Protein ID: WP_001609483.1
• Coordinates: 3055610..3055984 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J91_RS14345	3051946..3053481	-	1536	WP_001609560.1	EAL domain-containing protein	-
I6J91_RS14350	3053552..3054396	-	845	Protein_2793	DUF4942 domain-containing protein	-
I6J91_RS14355	3054492..3054689	-	198	WP_001609487.1	DUF957 domain-containing protein	-
I6J91_RS14360	3054701..3055189	-	489	WP_001609486.1	hypothetical protein	-
I6J91_RS14365	3055186..3055563	-	378	WP_001609485.1	TA system toxin CbtA family protein	Toxin
I6J91_RS14370	3055610..3055984	-	375	WP_001609483.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
I6J91_RS14375	3056034..3056678	-	645	WP_001609482.1	hypothetical protein	-
I6J91_RS14380	3056697..3056918	-	222	WP_001609480.1	DUF987 domain-containing protein	-
I6J91_RS14385	3056987..3057463	-	477	WP_001186188.1	RadC family protein	-
I6J91_RS14390	3057479..3057958	-	480	WP_001609479.1	antirestriction protein	-
I6J91_RS14395	3058040..3058858	-	819	WP_001609564.1	DUF945 domain-containing protein	-
I6J91_RS14400	3058957..3059268	-	312	WP_001608658.1	hypothetical protein	-
I6J91_RS14405	3059607..3059885	-	279	WP_001545361.1	hypothetical protein	-
I6J91_RS14410	3060146..3060826	-	681	WP_001608660.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14276.23 Da
• Isoelectric Point: 7.2141

>T190394 WP_001609485.1 NZ_CP069441:c3055563-3055186 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKYPEAKQ

Nucleotide

• Length: 378 bp

>T190394 NZ_CP091326:c3863098-3862730 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCATGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTATGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13675.54 Da
• Isoelectric Point: 6.4603

>AT190394 WP_001609483.1 NZ_CP069441:c3055984-3055610 [Escherichia coli]
VSDTLPGTTLPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQAFPLLMKQLKLMLTSG
ELNPCHQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTLAPATTS

Nucleotide

• Length: 375 bp

>AT190394 NZ_CP091326:c3863316-3863095 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA