Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | V | Classification (family/domain) | ghoTS/ghoT-GhoS |
Location | 3041791..3042288 | Replicon | chromosome |
Accession | NZ_CP069441 | ||
Organism | Escherichia coli strain FDAARGOS_1261 |
Toxin (Protein)
Gene name | ghoT | Uniprot ID | L4JJG6 |
Locus tag | I6J91_RS14315 | Protein ID | WP_001173343.1 |
Coordinates | 3042115..3042288 (+) | Length | 58 a.a. |
Antitoxin (Protein)
Gene name | ghoS | Uniprot ID | S1NQ59 |
Locus tag | I6J91_RS14310 | Protein ID | WP_001312331.1 |
Coordinates | 3041791..3042087 (+) | Length | 99 a.a. |
Genomic Context
Location: 3041048..3041278 (231 bp)
Type: Others
Protein ID: WP_000373291.1
Type: Others
Protein ID: WP_000373291.1
Location: 3041290..3041562 (273 bp)
Type: Others
Protein ID: WP_000405647.1
Type: Others
Protein ID: WP_000405647.1
Location: 3041791..3042087 (297 bp)
Type: Antitoxin
Protein ID: WP_001312331.1
Type: Antitoxin
Protein ID: WP_001312331.1
Location: 3042115..3042288 (174 bp)
Type: Toxin
Protein ID: WP_001173343.1
Type: Toxin
Protein ID: WP_001173343.1
Location: 3038520..3039239 (720 bp)
Type: Others
Protein ID: WP_000611288.1
Type: Others
Protein ID: WP_000611288.1
Location: 3039236..3040867 (1632 bp)
Type: Others
Protein ID: WP_001216466.1
Type: Others
Protein ID: WP_001216466.1
Location: 3042407..3043924 (1518 bp)
Type: Others
Protein ID: WP_000003805.1
Type: Others
Protein ID: WP_000003805.1
Location: 3044161..3045618 (1458 bp)
Type: Others
Protein ID: WP_000856828.1
Type: Others
Protein ID: WP_000856828.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6J91_RS14290 | 3038520..3039239 | - | 720 | WP_000611288.1 | two-component system response regulator DcuR | - |
I6J91_RS14295 | 3039236..3040867 | - | 1632 | WP_001216466.1 | sensor histidine kinase | - |
I6J91_RS14300 | 3041048..3041278 | + | 231 | WP_000373291.1 | (4Fe-4S)-binding protein | - |
I6J91_RS14305 | 3041290..3041562 | + | 273 | WP_000405647.1 | N-acetyltransferase | - |
I6J91_RS14310 | 3041791..3042087 | + | 297 | WP_001312331.1 | type V toxin-antitoxin system endoribonuclease antitoxin GhoS | Antitoxin |
I6J91_RS14315 | 3042115..3042288 | + | 174 | WP_001173343.1 | type V toxin-antitoxin system toxin GhoT | Toxin |
I6J91_RS14320 | 3042407..3043924 | - | 1518 | WP_000003805.1 | lysine--tRNA ligase | - |
I6J91_RS14325 | 3044161..3045618 | - | 1458 | WP_000856828.1 | dipeptide/tripeptide permease DtpC | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 58 a.a. Molecular weight: 6555.06 Da Isoelectric Point: 10.2288
>T190393 WP_001173343.1 NZ_CP069441:3042115-3042288 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF
Download Length: 174 bp
>T190393 NZ_CP091326:c3837134-3836787 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGAGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGAGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
Antitoxin
Download Length: 99 a.a. Molecular weight: 11440.95 Da Isoelectric Point: 4.1705
>AT190393 WP_001312331.1 NZ_CP069441:3041791-3042087 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK
Download Length: 297 bp
>AT190393 NZ_CP091326:c3836787-3836488 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QI41 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | S1NQ59 |