Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3041791..3042288 Replicon chromosome
Accession NZ_CP069441
Organism Escherichia coli strain FDAARGOS_1261

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag I6J91_RS14315 Protein ID WP_001173343.1
Coordinates 3042115..3042288 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag I6J91_RS14310 Protein ID WP_001312331.1
Coordinates 3041791..3042087 (+) Length 99 a.a.

Genomic Context


I6J91_RS14300I6J91_RS14305I6J91_RS14310I6J91_RS14315I6J91_RS14290I6J91_RS14295I6J91_RS14320I6J91_RS14325
Location: 3041048..3041278 (231 bp)
Type: Others
Protein ID: WP_000373291.1
Location: 3041290..3041562 (273 bp)
Type: Others
Protein ID: WP_000405647.1
Location: 3041791..3042087 (297 bp)
Type: Antitoxin
Protein ID: WP_001312331.1
Location: 3042115..3042288 (174 bp)
Type: Toxin
Protein ID: WP_001173343.1
Location: 3038520..3039239 (720 bp)
Type: Others
Protein ID: WP_000611288.1
Location: 3039236..3040867 (1632 bp)
Type: Others
Protein ID: WP_001216466.1
Location: 3042407..3043924 (1518 bp)
Type: Others
Protein ID: WP_000003805.1
Location: 3044161..3045618 (1458 bp)
Type: Others
Protein ID: WP_000856828.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6J91_RS142903038520..3039239-720WP_000611288.1two-component system response regulator DcuR-
I6J91_RS142953039236..3040867-1632WP_001216466.1sensor histidine kinase-
I6J91_RS143003041048..3041278+231WP_000373291.1(4Fe-4S)-binding protein-
I6J91_RS143053041290..3041562+273WP_000405647.1N-acetyltransferase-
I6J91_RS143103041791..3042087+297WP_001312331.1type V toxin-antitoxin system endoribonuclease antitoxin GhoSAntitoxin
I6J91_RS143153042115..3042288+174WP_001173343.1type V toxin-antitoxin system toxin GhoTToxin
I6J91_RS143203042407..3043924-1518WP_000003805.1lysine--tRNA ligase-
I6J91_RS143253044161..3045618-1458WP_000856828.1dipeptide/tripeptide permease DtpC-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-57)

Antitoxin

(5-94)


Sequences


Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T190393 WP_001173343.1 NZ_CP069441:3042115-3042288 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T190393 NZ_CP091326:c3837134-3836787 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGAGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT190393 WP_001312331.1 NZ_CP069441:3041791-3042087 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp

>AT190393 NZ_CP091326:c3836787-3836488 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A7U9QI41


Antitoxin

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Source
ID
Structure
AlphaFold DBS1NQ59

References