190391

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1684117..1684915 Replicon chromosome
Accession NZ_CP069441
Organism Escherichia coli strain FDAARGOS_1261

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M0HL60
Locus tag I6J91_RS07900 Protein ID WP_000854692.1
Coordinates 1684538..1684915 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1L4NTN5
Locus tag I6J91_RS07895 Protein ID WP_001605875.1
Coordinates 1684117..1684491 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J91_RS07875 1681864..1682682 + 819 WP_001234393.1 DUF945 domain-containing protein -
I6J91_RS07880 1682774..1683259 + 486 WP_000213727.1 antirestriction protein -
I6J91_RS07885 1683275..1683751 + 477 WP_001186181.1 RadC family protein -
I6J91_RS07890 1683820..1684041 + 222 WP_000692323.1 DUF987 domain-containing protein -
I6J91_RS07895 1684117..1684491 + 375 WP_001605875.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
I6J91_RS07900 1684538..1684915 + 378 WP_000854692.1 TA system toxin CbtA family protein Toxin
I6J91_RS07905 1684912..1685061 + 150 Protein_1544 hypothetical protein -
I6J91_RS07910 1685137..1685334 + 198 WP_023563519.1 DUF957 domain-containing protein -
I6J91_RS07915 1685419..1686261 + 843 WP_001280485.1 DUF4942 domain-containing protein -
I6J91_RS07920 1686604..1686774 + 171 Protein_1547 IS110 family transposase -
I6J91_RS07925 1687573..1688556 + 984 WP_048972910.1 KpsF/GutQ family sugar-phosphate isomerase -
I6J91_RS07930 1688628..1689776 + 1149 WP_000905920.1 capsule polysaccharide export inner-membrane protein KpsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1686670..1686774 104


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14119.12 Da        Isoelectric Point: 7.3249

>T190391 WP_000854692.1 NZ_CP069441:1684538-1684915 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWHTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

>T190391 NZ_CP091326:c2251416-2251314 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13594.42 Da        Isoelectric Point: 5.4554

>AT190391 WP_001605875.1 NZ_CP069441:1684117-1684491 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLACEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT190391 NZ_CP091326:2251307-2251452 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0HL60

Antitoxin

Source ID Structure
AlphaFold DB A0A1L4NTN5

References