Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4910006..4910801 Replicon chromosome
Accession NZ_CP069438
Organism Escherichia coli strain FDAARGOS_1260

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag I6J90_RS23720 Protein ID WP_000854914.1
Coordinates 4910427..4910801 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7UP42
Locus tag I6J90_RS23715 Protein ID WP_001280955.1
Coordinates 4910006..4910380 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J90_RS23685 4905361..4906266 + 906 WP_023149949.1 hypothetical protein -
I6J90_RS23690 4906263..4907333 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
I6J90_RS23695 4907673..4908491 + 819 WP_001234682.1 DUF945 domain-containing protein -
I6J90_RS23700 4908582..4909067 + 486 WP_000214398.1 antirestriction protein -
I6J90_RS23705 4909083..4909559 + 477 WP_001186738.1 RadC family protein -
I6J90_RS23710 4909622..4909843 + 222 WP_001220314.1 DUF987 domain-containing protein -
I6J90_RS23715 4910006..4910380 + 375 WP_001280955.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6J90_RS23720 4910427..4910801 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
I6J90_RS23725 4910798..4911289 + 492 WP_000976857.1 hypothetical protein -
I6J90_RS23730 4911301..4911498 + 198 WP_000839282.1 DUF957 domain-containing protein -
I6J90_RS23735 4911583..4912425 + 843 WP_001280481.1 DUF4942 domain-containing protein -
I6J90_RS23745 4912895..4913833 + 939 WP_000351277.1 glyoxylate/hydroxypyruvate reductase GhrA -
I6J90_RS23750 4913888..4914625 + 738 WP_000283664.1 zinc-binding phosphatase -
I6J90_RS23755 4914649..4915203 + 555 WP_001001921.1 molecular chaperone YcdY -
I6J90_RS23760 4915305..4915796 + 492 WP_001340063.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 4909083..4920732 11649


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T190369 WP_000854914.1 NZ_CP069438:4910427-4910801 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T190369 NZ_CP091308:2834338-2834634 [Burkholderia pyrrocinia]
ATGGAAAAGAGAAGGCCTCATTGCAAGCTGCCCCTCGTCAAGGCGCTGGTCGAATCCGGCAAGGTCCGGTTGACCACGAG
CGCGGTACTCGGCGCCCGGCAACTGGGTTTCACGGAAAGGGAGGCGCTCGATGTCGTGATGTCGCTGACCGACCTCGACT
TCCACAAGAGCATGACGACGTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCGTTGACGGTGCGTGGCGACGTG
TACCTGAAACTGACGGTGATCGACGAGGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13767.59 Da        Isoelectric Point: 6.6248

>AT190369 WP_001280955.1 NZ_CP069438:4910006-4910380 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT190369 NZ_CP091308:2834637-2835038 [Burkholderia pyrrocinia]
ATGAAGTGTCCTGCATGCGGTGCCGCCAAGCTGGTCCGCGACACGCGAGACATCCCTTATACCTACAAGGGCCGGTCGAC
TGTCGTCCGCGATATCACCGGCGATTTCTGCCCGGCCTGCGGGGAATCGGTACTGGATCTCGACGAGGCGACTCGTCTCG
GCGAAGCGATCGCCGAGTTCAACAAGCAGGTGAACGCAACCATCGTCGACCCGAAGTACATCGCGAAGGTGCGCAAGAAG
CTGAGGCTGGATCAGCGCGAGGCGGCCGAGCTCTTCGGCGGTGGCGTCAACGCGTTCTCCCGTTACGAGACAGGCAAGAC
GAATCCGCCGCTTGCCCTCGTGAAATTGCTGAAGATCCTGGATCGTCACCCCGATCTACTCGCCGAAGTCCGAGCGGCAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9P0D0

References