Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3837514..3838064 Replicon chromosome
Accession NZ_CP069438
Organism Escherichia coli strain FDAARGOS_1260

Toxin (Protein)


Gene name ccdB Uniprot ID S1PDG4
Locus tag I6J90_RS18670 Protein ID WP_001160966.1
Coordinates 3837750..3838064 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag I6J90_RS18665 Protein ID WP_000125566.1
Coordinates 3837514..3837747 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J90_RS18640 3832587..3832874 + 288 WP_000203741.1 ferredoxin-like protein FixX -
I6J90_RS18645 3832933..3834264 + 1332 WP_001183207.1 MFS transporter -
I6J90_RS18650 3834372..3834902 + 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
I6J90_RS18655 3834895..3836757 + 1863 WP_000377124.1 glutathione-regulated potassium-efflux system protein KefC -
I6J90_RS18660 3836949..3837428 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
I6J90_RS18665 3837514..3837747 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
I6J90_RS18670 3837750..3838064 + 315 WP_001160966.1 CcdB family protein Toxin
I6J90_RS18675 3838061..3838909 - 849 WP_000257182.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
I6J90_RS18680 3838916..3839293 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
I6J90_RS18685 3839296..3840117 - 822 WP_001065363.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
I6J90_RS18690 3840114..3841103 - 990 WP_000241229.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
I6J90_RS18695 3841103..3842389 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.72 Da        Isoelectric Point: 9.0851

>T190367 WP_001160966.1 NZ_CP069438:3837750-3838064 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T190367 NZ_CP091308:c1938674-1938357 [Burkholderia pyrrocinia]
ATGCCCTACAGTGCGCCTACGTACAGCATCCGGACCACCGACGTCTTCGACGCATGGTTTGCCGGCCTGCTGGATCGCGT
CGCGAAGCGCCGCATCCAGGCGCGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACTGGAAATCCGCCGGCTCGCCGG
TCGTCGAGATGCGTATCGACCATGGCCCCGGTTATCGCGTCTACTACGTCCGGCGCGGAACGATCTGGGTCATCCTGCTC
TGCGGCAGCGATAAATCGACGCAACAAGCCGACATACGCGCCGCGCACGCGATGCTTGCGCATCTCGACATGGAGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT190367 WP_000125566.1 NZ_CP069438:3837514-3837747 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT190367 NZ_CP091308:c1938353-1938054 [Burkholderia pyrrocinia]
ATGGACAAGATCAGCACCCGGCCGTGGGATTCGGCCGACCATCTGCAAACCGAAGACGACATGGCCGATTACTTCGAGGC
CTGCCTGCAAGAGGCCGGCGACGATCCGGCCTTCATCGCGCACGCGCTCGGCGTGATCGCACGCGCTCGCGGCATGTCGC
AGGTCGCGCGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAACCCGAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAACTGCACGGCTCGAAAGCGCGCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G815

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References