Detailed information of TA system TA190363

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3688630..3689450
• Replicon: chromosome
• Accession: NZ_CP069438
• Organism: Escherichia coli strain FDAARGOS_1260

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A0V9MKL8
• Locus tag: I6J90_RS17940
• Protein ID: WP_001550554.1
• Coordinates: 3689193..3689450 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: I6J90_RS17935
• Protein ID: WP_001519303.1
• Coordinates: 3688630..3689181 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J90_RS17900	3684325..3685638	-	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-
I6J90_RS17905	3685650..3685928	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
I6J90_RS17910	3685925..3687046	-	1122	WP_000010833.1	M42 family metallopeptidase	-
I6J90_RS17915	3687291..3687407	-	117	Protein_3496	VOC family protein	-
I6J90_RS17920	3687445..3687705	-	261	WP_000084876.1	hypothetical protein	-
I6J90_RS17925	3687832..3688380	-	549	WP_001519301.1	hypothetical protein	-
I6J90_RS17930	3688417..3688578	-	162	WP_001519302.1	hypothetical protein	-
I6J90_RS17935	3688630..3689181	-	552	WP_001519303.1	N-acetyltransferase	Antitoxin
I6J90_RS17940	3689193..3689450	-	258	WP_001550554.1	hypothetical protein	Toxin
I6J90_RS17945	3689827..3690126	-	300	WP_001519304.1	GNAT family N-acetyltransferase	-
I6J90_RS17950	3690189..3691430	+	1242	Protein_3503	DNA helicase	-
I6J90_RS17955	3692013..3692993	-	981	WP_001519307.1	transposase	-
I6J90_RS17960	3693058..3694164	-	1107	WP_001519308.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB / fimE / fimA / fimI / fimC	3688417..3700435	12018

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9744.33 Da
• Isoelectric Point: 11.0090

>T190363 WP_001550554.1 NZ_CP069438:c3689450-3689193 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T190363 NZ_CP091308:c1040094-1039813 [Burkholderia pyrrocinia]
ATGACCTTTGAGCTCGCCTTTCTCGAAGCTGCGTTGAAGGAGTGGAAGAAGCTCGATCGCACCGTTCGCGATCAGTTCAA
GGCCAGGCTCGCCGAACGGCTCGAGAATCCTCGCATTCCATCGGCGAAGCTGCACGGTCATCCGGACCGCTACAAGATCA
AGCTGCGCAGTGTCGGCTATCGCCTCGTGTACGAAGTGCGCGAGGCGGAAGTCGTCGTACTGGTTGTCGCGGTGGGCCGT
CGCGAGCGCGATGCGGTCTATCTCGCCGCCATGAAACGCTAG

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT190363 WP_001519303.1 NZ_CP069438:c3689181-3688630 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT190363 NZ_CP091308:c1040332-1040084 [Burkholderia pyrrocinia]
ATGCCCCACACCATCCTGGCCAGCGTGACGGCGAGCGTCTCGGAGCTGAAGCGGAACCCGATGGGAACCGTGGCGGCAGG
CGAGGGCTTCCCGGTCGCGATCCTGAATCACAACGAACCCGCGTTCTATTGCATCCCGGCGAAAACATGGGAGGCGATGG
TCGAACGTCTCGAAGATATCGAAGACAATGCGCTGGCCGACTCGCGCGCCAAGGAGAAAGCCGTCAAGGTCAAGCTGAAT
GACCTTTGA

Structures

Toxin

• AlphaFold DB: A0A0V9MKL8