Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3419494..3420329 Replicon chromosome
Accession NZ_CP069438
Organism Escherichia coli strain FDAARGOS_1260

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VR61
Locus tag I6J90_RS16545 Protein ID WP_000854747.1
Coordinates 3419494..3419871 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3P1Z1K5
Locus tag I6J90_RS16550 Protein ID WP_021538665.1
Coordinates 3419961..3420329 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J90_RS16525 3415586..3417124 - 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -
I6J90_RS16530 3417861..3418715 - 855 WP_001588930.1 DUF4942 domain-containing protein -
I6J90_RS16535 3418800..3418997 - 198 WP_000839291.1 DUF957 domain-containing protein -
I6J90_RS16540 3419009..3419497 - 489 WP_059342216.1 hypothetical protein -
I6J90_RS16545 3419494..3419871 - 378 WP_000854747.1 TA system toxin CbtA family protein Toxin
I6J90_RS16550 3419961..3420329 - 369 WP_021538665.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6J90_RS16555 3420404..3420625 - 222 WP_001825901.1 DUF987 domain-containing protein -
I6J90_RS16560 3420688..3421164 - 477 WP_001186727.1 RadC family protein -
I6J90_RS16565 3421180..3421665 - 486 WP_021566656.1 antirestriction protein -
I6J90_RS16570 3421757..3422575 - 819 WP_001234693.1 DUF945 domain-containing protein -
I6J90_RS16575 3422676..3422909 - 234 WP_021538212.1 DUF905 family protein -
I6J90_RS16580 3422915..3423592 - 678 WP_001097364.1 hypothetical protein -
I6J90_RS16585 3423711..3424595 - 885 WP_000010387.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3408097..3433076 24979


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14095.03 Da        Isoelectric Point: 6.8524

>T190362 WP_000854747.1 NZ_CP069438:c3419871-3419494 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ

Download         Length: 378 bp

>T190362 NZ_CP091308:386708-387289 [Burkholderia pyrrocinia]
ATGAACCCCGACACGATCCACGCGCGGCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACGGCCGAGCATAGCTGGCGGCTGTGCCTGACGGCGCTCGTGTTCGCCGACGCGC
TGCCCGGCATCGATACGCAGAAGCTGCTGAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATTCCC
GCGATCGAGCAGGCCGCGCACCCGGACAAAAGCGCGCACGAACGCGACGACCTGCTGACGCTGACGGCGTCGCTCGATCG
CACGCTGCGCGACGAGATCGTCGCGCTGTGGGATGAATACGAGGCGGCCGCGTCGCCGGAAGCGCGCGCGGCAAAGGCGC
TCGACAAGCTCGAGACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACCGATGCCGCGCCGCTGTTCAGTGCGATCCGCGACATCGTCGATGCCGATACGCAACGCCGGATCGA
CGCGGGCGGGCAGCGCGCGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13465.18 Da        Isoelectric Point: 6.2015

>AT190362 WP_021538665.1 NZ_CP069438:c3420329-3419961 [Escherichia coli]
VSDTFSGTTHPDDNRGRPWWGLPCTVTPCFGARLVQEGNQLHYLADHAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGCVYLAVYPTPETKK

Download         Length: 369 bp

>AT190362 NZ_CP091308:386071-386628 [Burkholderia pyrrocinia]
ATGACCGCCTCGCCATTACACACGCCACCGCTCGGCCCGCAACTCAAGCGCTGGCGCGCACTGCACCGCGTGAAGCAAAG
CCACGCCGCGGAACTGTTCGGCGTCGCGCAATCGACGATCTCCCGCTGGGAAGCCGGTATCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCCGAGCGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGACCACGCGCTCGCGCGGCTCATCGCGGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTCGCCAGTTCGCCGGCGCGCACGGCCGAGTTCTC
GCAGCCGCTTTCGATGCTGCTCGGCGCGTCGCTGTGGCGCTACGCGACGCCGGAGATCGTCCGCATGGAAGCCGCGCTCG
ACACGCTCGGCTGGCACGATCGCGCGGGGCCGCCGAGCGTCGAATTCGATACCGGCGCGAATGCATCGCGCGTCGTGCCG
ATCCGTGGCAGCACGTGCCGGTGGACGCGGATGACGCTGTCGGACGGTTCGGCCGCGCGGCTCGTCGAAACGCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2VFZ1

Antitoxin

Source ID Structure
AlphaFold DB A0A3P1Z1K5

References