Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 3419494..3420329 | Replicon | chromosome |
Accession | NZ_CP069438 | ||
Organism | Escherichia coli strain FDAARGOS_1260 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | Q8VR61 |
Locus tag | I6J90_RS16545 | Protein ID | WP_000854747.1 |
Coordinates | 3419494..3419871 (-) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | A0A3P1Z1K5 |
Locus tag | I6J90_RS16550 | Protein ID | WP_021538665.1 |
Coordinates | 3419961..3420329 (-) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6J90_RS16525 | 3415586..3417124 | - | 1539 | WP_001187191.1 | lysine decarboxylation/transport transcriptional activator CadC | - |
I6J90_RS16530 | 3417861..3418715 | - | 855 | WP_001588930.1 | DUF4942 domain-containing protein | - |
I6J90_RS16535 | 3418800..3418997 | - | 198 | WP_000839291.1 | DUF957 domain-containing protein | - |
I6J90_RS16540 | 3419009..3419497 | - | 489 | WP_059342216.1 | hypothetical protein | - |
I6J90_RS16545 | 3419494..3419871 | - | 378 | WP_000854747.1 | TA system toxin CbtA family protein | Toxin |
I6J90_RS16550 | 3419961..3420329 | - | 369 | WP_021538665.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
I6J90_RS16555 | 3420404..3420625 | - | 222 | WP_001825901.1 | DUF987 domain-containing protein | - |
I6J90_RS16560 | 3420688..3421164 | - | 477 | WP_001186727.1 | RadC family protein | - |
I6J90_RS16565 | 3421180..3421665 | - | 486 | WP_021566656.1 | antirestriction protein | - |
I6J90_RS16570 | 3421757..3422575 | - | 819 | WP_001234693.1 | DUF945 domain-containing protein | - |
I6J90_RS16575 | 3422676..3422909 | - | 234 | WP_021538212.1 | DUF905 family protein | - |
I6J90_RS16580 | 3422915..3423592 | - | 678 | WP_001097364.1 | hypothetical protein | - |
I6J90_RS16585 | 3423711..3424595 | - | 885 | WP_000010387.1 | 50S ribosome-binding GTPase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 3408097..3433076 | 24979 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14095.03 Da Isoelectric Point: 6.8524
>T190362 WP_000854747.1 NZ_CP069438:c3419871-3419494 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ
Download Length: 378 bp
>T190362 NZ_CP091308:386708-387289 [Burkholderia pyrrocinia]
ATGAACCCCGACACGATCCACGCGCGGCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACGGCCGAGCATAGCTGGCGGCTGTGCCTGACGGCGCTCGTGTTCGCCGACGCGC
TGCCCGGCATCGATACGCAGAAGCTGCTGAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATTCCC
GCGATCGAGCAGGCCGCGCACCCGGACAAAAGCGCGCACGAACGCGACGACCTGCTGACGCTGACGGCGTCGCTCGATCG
CACGCTGCGCGACGAGATCGTCGCGCTGTGGGATGAATACGAGGCGGCCGCGTCGCCGGAAGCGCGCGCGGCAAAGGCGC
TCGACAAGCTCGAGACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACCGATGCCGCGCCGCTGTTCAGTGCGATCCGCGACATCGTCGATGCCGATACGCAACGCCGGATCGA
CGCGGGCGGGCAGCGCGCGTAA
ATGAACCCCGACACGATCCACGCGCGGCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACGGCCGAGCATAGCTGGCGGCTGTGCCTGACGGCGCTCGTGTTCGCCGACGCGC
TGCCCGGCATCGATACGCAGAAGCTGCTGAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATTCCC
GCGATCGAGCAGGCCGCGCACCCGGACAAAAGCGCGCACGAACGCGACGACCTGCTGACGCTGACGGCGTCGCTCGATCG
CACGCTGCGCGACGAGATCGTCGCGCTGTGGGATGAATACGAGGCGGCCGCGTCGCCGGAAGCGCGCGCGGCAAAGGCGC
TCGACAAGCTCGAGACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACCGATGCCGCGCCGCTGTTCAGTGCGATCCGCGACATCGTCGATGCCGATACGCAACGCCGGATCGA
CGCGGGCGGGCAGCGCGCGTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13465.18 Da Isoelectric Point: 6.2015
>AT190362 WP_021538665.1 NZ_CP069438:c3420329-3419961 [Escherichia coli]
VSDTFSGTTHPDDNRGRPWWGLPCTVTPCFGARLVQEGNQLHYLADHAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGCVYLAVYPTPETKK
VSDTFSGTTHPDDNRGRPWWGLPCTVTPCFGARLVQEGNQLHYLADHAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGCVYLAVYPTPETKK
Download Length: 369 bp
>AT190362 NZ_CP091308:386071-386628 [Burkholderia pyrrocinia]
ATGACCGCCTCGCCATTACACACGCCACCGCTCGGCCCGCAACTCAAGCGCTGGCGCGCACTGCACCGCGTGAAGCAAAG
CCACGCCGCGGAACTGTTCGGCGTCGCGCAATCGACGATCTCCCGCTGGGAAGCCGGTATCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCCGAGCGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGACCACGCGCTCGCGCGGCTCATCGCGGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTCGCCAGTTCGCCGGCGCGCACGGCCGAGTTCTC
GCAGCCGCTTTCGATGCTGCTCGGCGCGTCGCTGTGGCGCTACGCGACGCCGGAGATCGTCCGCATGGAAGCCGCGCTCG
ACACGCTCGGCTGGCACGATCGCGCGGGGCCGCCGAGCGTCGAATTCGATACCGGCGCGAATGCATCGCGCGTCGTGCCG
ATCCGTGGCAGCACGTGCCGGTGGACGCGGATGACGCTGTCGGACGGTTCGGCCGCGCGGCTCGTCGAAACGCTCTAG
ATGACCGCCTCGCCATTACACACGCCACCGCTCGGCCCGCAACTCAAGCGCTGGCGCGCACTGCACCGCGTGAAGCAAAG
CCACGCCGCGGAACTGTTCGGCGTCGCGCAATCGACGATCTCCCGCTGGGAAGCCGGTATCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCCGAGCGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGACCACGCGCTCGCGCGGCTCATCGCGGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTCGCCAGTTCGCCGGCGCGCACGGCCGAGTTCTC
GCAGCCGCTTTCGATGCTGCTCGGCGCGTCGCTGTGGCGCTACGCGACGCCGGAGATCGTCCGCATGGAAGCCGCGCTCG
ACACGCTCGGCTGGCACGATCGCGCGGGGCCGCCGAGCGTCGAATTCGATACCGGCGCGAATGCATCGCGCGTCGTGCCG
ATCCGTGGCAGCACGTGCCGGTGGACGCGGATGACGCTGTCGGACGGTTCGGCCGCGCGGCTCGTCGAAACGCTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H2VFZ1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3P1Z1K5 |