Detailed information of TA system TA190357

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 2006689..2007970
• Replicon: chromosome
• Accession: NZ_CP069438
• Organism: Escherichia coli strain FDAARGOS_1260

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: I6J90_RS09890
• Protein ID: WP_059342195.1
• Coordinates: 2007077..2007970 (+)
• Length: 298 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: V0YCI1
• Locus tag: I6J90_RS09885
• Protein ID: WP_000208383.1
• Coordinates: 2006689..2007084 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J90_RS09840	2002184..2002669	+	486	WP_059342223.1	antirestriction protein	-
I6J90_RS09845	2002685..2003161	+	477	WP_001186726.1	RadC family protein	-
I6J90_RS09850	2003224..2003445	+	222	WP_000692329.1	DUF987 domain-containing protein	-
I6J90_RS09855	2003464..2004108	+	645	WP_000094916.1	hypothetical protein	-
I6J90_RS09860	2004158..2004538	+	381	WP_001285598.1	type IV toxin-antitoxin system YeeU family antitoxin	-
I6J90_RS09865	2004615..2004992	+	378	WP_000854689.1	TA system toxin CbtA family protein	-
I6J90_RS09870	2004989..2005476	+	488	Protein_1932	hypothetical protein	-
I6J90_RS09875	2005493..2005690	+	198	WP_000839293.1	DUF957 domain-containing protein	-
I6J90_RS09880	2005775..2006620	+	846	WP_023281696.1	DUF4942 domain-containing protein	-
I6J90_RS09885	2006689..2007084	+	396	WP_000208383.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
I6J90_RS09890	2007077..2007970	+	894	WP_059342195.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I6J90_RS09895	2008441..2008611	+	171	Protein_1937	IS110 family transposase	-
I6J90_RS09900	2008960..2010459	+	1500	WP_000174401.1	IS21-like element ISEc10 family transposase	-
I6J90_RS09905	2010456..2011211	+	756	Protein_1939	IS21-like element ISEc10 family helper ATPase IstB	-
I6J90_RS09910	2011837..2012820	+	984	WP_001296394.1	KpsF/GutQ family sugar-phosphate isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (34-292)

Antitoxin

• Protein of unknown function DUF6088 (10-129)

Sequences

Toxin

Protein

• Length: 298 a.a.
• Molecular weight: 34270.35 Da
• Isoelectric Point: 5.9850

>T190357 WP_059342195.1 NZ_CP069438:2007077-2007970 [Escherichia coli]
MPELTSLFPDVADALDIESAAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN

Nucleotide

• Length: 894 bp

>T190357 NZ_CP091307:c1695418-1695008 [Burkholderia pyrrocinia]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATCTGATGAAGAATCAGCCGGAGCAGGTCGCAAGACGGTTTGC
GCAGTGTTACACGGGGGACGTCGTGATGTCGGCGGTCACGTATGCCGAGCTCGAGTACGGTGTCGCGGTGTGCGCGAATC
CTGACCGGGAGCGTCTAAATCTTTCCGCGCTGATCGAGGATATTCCCGTTGCGCCGTTCGATGTGGCGGCTGCGCAAGCG
TACGGTCCTGTTCGCGAAGCGACCCGCGAACGGAAGAAGGATCATCTCGACAAGCTGATCGCGGCCCACGCGGTGTCGCT
CGATGTCGCCCTCGTGACCAACAACGAGCGGGATTTTGTGAGCTATCCGGGGTTGCGGATGGAGAACTGGCTGAACGATT
CGTGTCCGTGA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14608.03 Da
• Isoelectric Point: 11.3150

>AT190357 WP_000208383.1 NZ_CP069438:2006689-2007084 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA

Nucleotide

• Length: 396 bp

>AT190357 NZ_CP091307:c1695654-1695418 [Burkholderia pyrrocinia]
ATGCATACCACCAGGGTATTTCGGAACGGCAACTCGCAGGCCGTACGGATTCCAGCGGACCTTGCTTATGAGCGCAGCGA
CATCGAACTGGAAATCGAGCGGGTGGGTGACGAAATCCGTATTCGGCCTATGCGGCGGCCTCTGACCCGTGTGCTCGAGA
AGTTTGCAAAATTCGGGCCGGATTTCATGTCCGAAGGACGTGGCGATCAGGAGCAGGCTGAGCGCGAGGGTCTGTGA

Structures

Antitoxin

• AlphaFold DB: V0YCI1