190340

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1253278..1254195 Replicon chromosome
Accession NZ_CP069430
Organism Bacillus velezensis strain TB918

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag JQN69_RS06520 Protein ID WP_007407256.1
Coordinates 1253449..1254195 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag JQN69_RS06515 Protein ID WP_003154807.1
Coordinates 1253278..1253448 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQN69_RS06480 1248502..1250133 + 1632 WP_052827325.1 hypothetical protein -
JQN69_RS06485 1250146..1250517 + 372 WP_043021266.1 YomQ/XkdW protein, phage-like element PBSX -
JQN69_RS06490 1250522..1250719 + 198 WP_012117366.1 XkdX family protein -
JQN69_RS06495 1250776..1251537 + 762 WP_015239693.1 hypothetical protein -
JQN69_RS06500 1251589..1251852 + 264 WP_003154815.1 hemolysin XhlA family protein -
JQN69_RS06505 1251866..1252129 + 264 WP_003154813.1 phage holin -
JQN69_RS06510 1252143..1253021 + 879 WP_020955695.1 N-acetylmuramoyl-L-alanine amidase -
JQN69_RS06515 1253278..1253448 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
JQN69_RS06520 1253449..1254195 - 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
JQN69_RS06525 1254300..1255298 - 999 WP_007407255.1 inorganic phosphate transporter -
JQN69_RS06530 1255311..1255928 - 618 WP_003154804.1 DUF47 domain-containing protein -
JQN69_RS06535 1256214..1257530 - 1317 WP_007407254.1 amino acid permease -
JQN69_RS06540 1257855..1258805 + 951 WP_012117369.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T190340 WP_007407256.1 NZ_CP069430:c1254195-1253449 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

>T190340 NZ_CP091300:200800-200903 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT190340 WP_003154807.1 NZ_CP069430:c1253448-1253278 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp

>AT190340 NZ_CP091300:c200905-200762 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References