Detailed information of TA system TA190335

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1045928..1046678
• Replicon: chromosome
• Accession: NZ_CP069389
• Organism: Mammaliicoccus sciuri strain GDQ20D70P

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: JRU67_RS05335
• Protein ID: WP_101494413.1
• Coordinates: 1046571..1046678 (+)
• Length: 36 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A657XLL6
• Locus tag: JRU67_RS05330
• Protein ID: WP_025904800.1
• Coordinates: 1045928..1046527 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JRU67_RS05305	1041609..1042370	+	762	WP_198471990.1	acetylglutamate kinase	-
JRU67_RS05310	1042861..1043988	+	1128	WP_198471991.1	tRNA epoxyqueuosine(34) reductase QueG	-
JRU67_RS05315	1043992..1044465	+	474	WP_025904798.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
JRU67_RS05320	1044500..1044640	-	141	WP_162841915.1	hypothetical protein	-
JRU67_RS05325	1044727..1045878	+	1152	WP_204178282.1	N-acetylglucosamine-6-phosphate deacetylase	-
JRU67_RS05330	1045928..1046527	+	600	WP_025904800.1	glucosamine-6-phosphate isomerase	Antitoxin
JRU67_RS05335	1046571..1046678	+	108	WP_101494413.1	hypothetical protein	Toxin
JRU67_RS05340	1046832..1048220	+	1389	WP_107577221.1	class II fumarate hydratase	-
JRU67_RS05345	1048310..1049836	+	1527	WP_126477940.1	exopolyphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (134-195)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4130.43 Da
• Isoelectric Point: 3.7615

>T190335 WP_101494413.1 NZ_CP069389:1046571-1046678 [Mammaliicoccus sciuri]
MVQDLEDVKELGKEMEQISEQNDEAFEEKKSEQES

Nucleotide

• Length: 108 bp

>T190335 NZ_CP091289:c2654270-2653887 [Lacticaseibacillus paracasei subsp. paracasei]
ATGGATGTGTCCGTAAAACGCGGCGATGTTTTTTTCGCCGATCTGTCTCCGGTTGTCGGCTCCGAACAAGGCGGCAACCG
GCCAGTACTTATTATTCAAAACAACGTTGGCAACCATTACAGTCCCACAGTGATTGTGGCAGCCATTACCTCCAAGATTC
AAAAACCCAAGATGCCGACGCATGTCGGGTTACGGGCCAAGCAAGATGGCGTCGAACGCAATTCGGTCATTTTACTTGAG
CAAATTCGCACGATTGACAAGCAACGGCTACAAGCCCGCGTGACAGCTCTGTCAAGCACCAAAATGGCAGCAGTCGACCG
CGCGTTGGCGATTTCAGTGGGTCTGGTCAGTTTGCCCAAGCCCAAAACATATAATAAGAATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22291.16 Da
• Isoelectric Point: 4.8551

>AT190335 WP_025904800.1 NZ_CP069389:1045928-1046527 [Mammaliicoccus sciuri]
MALNFKVFETKDIAARYAADVVRKQFNSDSTSVVGVHLEAEQTSFFDELLDDVKKNPVNFSQIHILDFDGKEDYYTELGV
PAKQVLKTDVGSDVEAFIKEKVNTDKKKNKLMLDVVTLTEDSRTGLDYDQAIHPAREVIVLVTGKEKAKAVSQLYQEPAN
GSVESAKLKQHRMVTVVLDNEAAQGLPEDVRSYFSIQFS

Nucleotide

• Length: 600 bp

>AT190335 NZ_CP091289:c2654538-2654290 [Lacticaseibacillus paracasei subsp. paracasei]
ATGAAAAAGCAAACGTCAGTAGCGGTAACGTTTGATGATGCCATTAAGGCGCGGTTGGATGCCTATTGTGAATTGAATGA
CATTGACGCTCAGGCTGTGATTACGGAGGCAGTGGCGACATTTTTGAAGTCACAGGCTCCCGAAATCAACCAATTGATTT
CGGGCTATGTAGCAATGGGCCAGATCAATACAGAGATCAGTCATGCTTTCTCTGCCTGCGAGAGCGAGGCATACGCCCAT
ATTCGATGA

Structures

Antitoxin

• AlphaFold DB: A0A657XLL6