Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3865281..3865899 | Replicon | chromosome |
Accession | NZ_CP069386 | ||
Organism | Escherichia coli strain XH1815 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | H5UYE2 |
Locus tag | JSW75_RS18725 | Protein ID | WP_001291435.1 |
Coordinates | 3865281..3865499 (-) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | S1PTH5 |
Locus tag | JSW75_RS18730 | Protein ID | WP_000344800.1 |
Coordinates | 3865525..3865899 (-) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JSW75_RS18690 (3860570) | 3860570..3861142 | + | 573 | WP_000779842.1 | YbaY family lipoprotein | - |
JSW75_RS18695 (3861173) | 3861173..3861484 | - | 312 | WP_000409911.1 | MGMT family protein | - |
JSW75_RS18705 (3861863) | 3861863..3862216 | + | 354 | WP_000878140.1 | DUF1428 domain-containing protein | - |
JSW75_RS18710 (3862258) | 3862258..3863808 | - | 1551 | WP_001310610.1 | cyclic-guanylate-specific phosphodiesterase PdeB | - |
JSW75_RS18715 (3863972) | 3863972..3864442 | - | 471 | WP_001716237.1 | YlaC family protein | - |
JSW75_RS18720 (3864558) | 3864558..3865109 | - | 552 | WP_000102564.1 | maltose O-acetyltransferase | - |
JSW75_RS18725 (3865281) | 3865281..3865499 | - | 219 | WP_001291435.1 | HHA domain-containing protein | Toxin |
JSW75_RS18730 (3865525) | 3865525..3865899 | - | 375 | WP_000344800.1 | Hha toxicity modulator TomB | Antitoxin |
JSW75_RS18735 (3866445) | 3866445..3869594 | - | 3150 | WP_001132469.1 | efflux RND transporter permease AcrB | - |
JSW75_RS18740 (3869617) | 3869617..3870810 | - | 1194 | WP_001295324.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T190326 WP_001291435.1 NZ_CP069386:c3865499-3865281 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T190326 NZ_CP091245:15476-15778 [Thiothrix winogradskyi]
ATGCCATCATTAATTTTTAGCCATACCGCCCTACTGGACTTAGAGCGGTTACGGGCATTCTTACGCGCCAAAAACCGACC
AGCCGCCCGCCGTGCCGTGGTCAAGATCATGCAAGGGTTGCAGGCACTGGAACAGCACCCGGAGCTAGGTCACACGGTGG
AAGACCGACCGGAAGACTACCGCGAGCTAGTGATTCCCTTCGGCAAAGACGGCTACATTGCCGCCTACCGTTACGCGGGG
GATTCGCTGGTGGTGTTGGGTGTCCGCCATCAACGCGAGTTACAGCCGCCTACCCTGCCCTAA
ATGCCATCATTAATTTTTAGCCATACCGCCCTACTGGACTTAGAGCGGTTACGGGCATTCTTACGCGCCAAAAACCGACC
AGCCGCCCGCCGTGCCGTGGTCAAGATCATGCAAGGGTTGCAGGCACTGGAACAGCACCCGGAGCTAGGTCACACGGTGG
AAGACCGACCGGAAGACTACCGCGAGCTAGTGATTCCCTTCGGCAAAGACGGCTACATTGCCGCCTACCGTTACGCGGGG
GATTCGCTGGTGGTGTTGGGTGTCCGCCATCAACGCGAGTTACAGCCGCCTACCCTGCCCTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14557.39 Da Isoelectric Point: 4.7395
>AT190326 WP_000344800.1 NZ_CP069386:c3865899-3865525 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
Download Length: 375 bp
>AT190326 NZ_CP091245:15195-15488 [Thiothrix winogradskyi]
ATGTCACAAGTTGTTTCCATTGCACCTACCTCTATCAAACTGGACGTAGACACCAAAACTCGCCTGCAACGCTTGGCAAC
CTCGCGCCAGCGTTCCACCCATTGGCTGATGCAAGAAGCCATCCGCCAGTATTTGGAGCGTGAGGAACAATTGGCGCAGT
TCCGCGACGAAATGCAAACCGCGTGGGATGATTACCAAGACACTGGCTTACACGTCACTGGCAAAGAAGTGTTTGCTTGG
ATGGAAACATGGTTCACTGATAGCGAAGCCCAGCCCCCCAAATGCCATCATTAA
ATGTCACAAGTTGTTTCCATTGCACCTACCTCTATCAAACTGGACGTAGACACCAAAACTCGCCTGCAACGCTTGGCAAC
CTCGCGCCAGCGTTCCACCCATTGGCTGATGCAAGAAGCCATCCGCCAGTATTTGGAGCGTGAGGAACAATTGGCGCAGT
TCCGCGACGAAATGCAAACCGCGTGGGATGATTACCAAGACACTGGCTTACACGTCACTGGCAAAGAAGTGTTTGCTTGG
ATGGAAACATGGTTCACTGATAGCGAAGCCCAGCCCCCCAAATGCCATCATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 2MW2 | |
PDB | 1JW2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QBQ5 |