Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 3295663..3297385 | Replicon | chromosome |
| Accession | NZ_CP069386 | ||
| Organism | Escherichia coli strain XH1815 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A0A0U2S2I2 |
| Locus tag | JSW75_RS15855 | Protein ID | WP_064497040.1 |
| Coordinates | 3296447..3297385 (+) | Length | 313 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A0A934MVJ4 |
| Locus tag | JSW75_RS15850 | Protein ID | WP_000095577.1 |
| Coordinates | 3295663..3296454 (+) | Length | 264 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JSW75_RS15820 (3291336) | 3291336..3291617 | + | 282 | WP_000433889.1 | type IV conjugative transfer system protein TraL | - |
| JSW75_RS15825 (3291614) | 3291614..3292240 | + | 627 | WP_000667170.1 | TraE/TraK family type IV conjugative transfer system protein | - |
| JSW75_RS15830 (3292224) | 3292224..3293120 | + | 897 | WP_048608549.1 | type-F conjugative transfer system secretin TraK | - |
| JSW75_RS15835 (3293123) | 3293123..3294412 | + | 1290 | WP_143475779.1 | TraB/VirB10 family protein | - |
| JSW75_RS15840 (3294487) | 3294487..3295059 | + | 573 | WP_024008834.1 | type IV conjugative transfer system lipoprotein TraV | - |
| JSW75_RS15845 (3295056) | 3295056..3295442 | + | 387 | WP_032469918.1 | TraA family conjugative transfer protein | - |
| JSW75_RS15850 (3295663) | 3295663..3296454 | + | 792 | WP_000095577.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| JSW75_RS15855 (3296447) | 3296447..3297385 | + | 939 | WP_064497040.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| JSW75_RS15860 (3297517) | 3297517..3298209 | + | 693 | WP_001228924.1 | DsbC family protein | - |
| JSW75_RS15865 (3298209) | 3298209..3300608 | + | 2400 | WP_064497039.1 | type IV secretion system protein TraC | - |
| JSW75_RS15870 (3300601) | 3300601..3300948 | + | 348 | WP_064497038.1 | hypothetical protein | - |
| JSW75_RS15875 (3300932) | 3300932..3301444 | + | 513 | WP_175215521.1 | S26 family signal peptidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | erm(42) / floR / aph(6)-Id / aph(3')-VIa / aph(3'')-Ib / sul2 / tet(C) / fosA3 / blaCTX-M-65 / aph(4)-Ia / aac(3)-IVa / aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / qacE / sul1 | - | 3235635..3359700 | 124065 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 35542.81 Da Isoelectric Point: 4.9912
>T190322 WP_064497040.1 NZ_CP069386:3296447-3297385 [Escherichia coli]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIIVSSPVATIKIEVSPVARGTLHSAEIMAVQESVEYEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGVSREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLTSLQK
HFTERDYAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIIVSSPVATIKIEVSPVARGTLHSAEIMAVQESVEYEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGVSREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLTSLQK
HFTERDYAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
Download Length: 939 bp
>T190322 NZ_CP091244:1360614-1360868 [Thiothrix winogradskyi]
ATGCTGTTATGTTGGGCTGATGATGCATGGGATGATTACCTACACTGGCAGCAAACCGACCGCAAAATCTTGAAGCGGGT
GAATGATCTAATCAAGGATATGAAGCGCAACCCGTTTGAAGGCGTGGGCAAACCCGAACCACTCAAGCACCAGTGGGCGG
GGTATTGGTCAAGGCGCATCACGGAAGAACACCGGATTGTCTATAAGGTGGAAAGTGACCACCTGTATATTGCTCAATGC
CGTTACCACTATTAA
ATGCTGTTATGTTGGGCTGATGATGCATGGGATGATTACCTACACTGGCAGCAAACCGACCGCAAAATCTTGAAGCGGGT
GAATGATCTAATCAAGGATATGAAGCGCAACCCGTTTGAAGGCGTGGGCAAACCCGAACCACTCAAGCACCAGTGGGCGG
GGTATTGGTCAAGGCGCATCACGGAAGAACACCGGATTGTCTATAAGGTGGAAAGTGACCACCTGTATATTGCTCAATGC
CGTTACCACTATTAA
Antitoxin
Download Length: 264 a.a. Molecular weight: 30109.49 Da Isoelectric Point: 9.5097
>AT190322 WP_000095577.1 NZ_CP069386:3295663-3296454 [Escherichia coli]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
Download Length: 792 bp
>AT190322 NZ_CP091244:1360357-1360614 [Thiothrix winogradskyi]
ATGGAAGCCATCAGTTATTCAGCTTTCAGAAAAGGGCTATCGAATGCCTTGGATAAGGTGGAGCAAGACCGCGTACCCCT
GTTGATTACCCGGCAGAACGGCACGGCAGCGGTGCTTATTTCCTTGGATGAATACAACGCCTATGCAGAAACCGCGCATT
TGGCAGCAAGCCCCAAAAATGCCGAACGCTTGAACCGTGCTATTGCCCAACTGGAAGCAGGGCGGGGCGTGGTGCGTGAC
ATCGTGGAGGGGGAATAA
ATGGAAGCCATCAGTTATTCAGCTTTCAGAAAAGGGCTATCGAATGCCTTGGATAAGGTGGAGCAAGACCGCGTACCCCT
GTTGATTACCCGGCAGAACGGCACGGCAGCGGTGCTTATTTCCTTGGATGAATACAACGCCTATGCAGAAACCGCGCATT
TGGCAGCAAGCCCCAAAAATGCCGAACGCTTGAACCGTGCTATTGCCCAACTGGAAGCAGGGCGGGGCGTGGTGCGTGAC
ATCGTGGAGGGGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|