Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3076463..3077058 Replicon chromosome
Accession NZ_CP069386
Organism Escherichia coli strain XH1815

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag JSW75_RS14775 Protein ID WP_000239577.1
Coordinates 3076708..3077058 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag JSW75_RS14770 Protein ID WP_001223208.1
Coordinates 3076463..3076714 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSW75_RS14760 (3072128) 3072128..3075907 + 3780 WP_000060911.1 autotransporter assembly complex protein TamB -
JSW75_RS14765 (3075910) 3075910..3076251 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
JSW75_RS14770 (3076463) 3076463..3076714 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
JSW75_RS14775 (3076708) 3076708..3077058 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
JSW75_RS14780 (3077138) 3077138..3077668 - 531 WP_000055075.1 inorganic diphosphatase -
JSW75_RS14785 (3077978) 3077978..3078934 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
JSW75_RS14790 (3079074) 3079074..3080576 + 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
JSW75_RS14795 (3080590) 3080590..3081612 + 1023 WP_001313531.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T190316 WP_000239577.1 NZ_CP069386:3076708-3077058 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T190316 NZ_CP091240:2728131-2728274 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT190316 WP_001223208.1 NZ_CP069386:3076463-3076714 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT190316 NZ_CP091240:c2728034-2727833 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTGTAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGCGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References