Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1401898..1402565 Replicon chromosome
Accession NZ_CP069386
Organism Escherichia coli strain XH1815

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag JSW75_RS06825 Protein ID WP_001094400.1
Coordinates 1402236..1402565 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag JSW75_RS06820 Protein ID WP_000072690.1
Coordinates 1401898..1402215 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSW75_RS06790 (1396950) 1396950..1397959 - 1010 Protein_1334 arsenic transporter -
JSW75_RS06795 (1398101) 1398101..1399804 + 1704 WP_000896263.1 protein YfjW -
JSW75_RS06800 (1400415) 1400415..1400599 + 185 Protein_1336 DUF905 domain-containing protein -
JSW75_RS06805 (1400702) 1400702..1401160 + 459 WP_000211841.1 antirestriction protein -
JSW75_RS06810 (1401169) 1401169..1401651 + 483 WP_001407480.1 RadC family protein -
JSW75_RS06815 (1401660) 1401660..1401860 + 201 WP_001395452.1 DUF987 domain-containing protein -
JSW75_RS06820 (1401898) 1401898..1402215 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JSW75_RS06825 (1402236) 1402236..1402565 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
JSW75_RS06830 (1402929) 1402929..1407509 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T190307 WP_001094400.1 NZ_CP069386:1402236-1402565 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

>T190307 NZ_CP091240:c320472-320377 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT190307 WP_000072690.1 NZ_CP069386:1401898-1402215 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT190307 NZ_CP091240:320278-320342 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGTGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
PDB 2EA9
PDB 2JN7
AlphaFold DB P52141

References