Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 707428..708259 Replicon chromosome
Accession NZ_CP069386
Organism Escherichia coli strain XH1815

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag JSW75_RS03575 Protein ID WP_000854814.1
Coordinates 707885..708259 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID P76364
Locus tag JSW75_RS03570 Protein ID WP_001285584.1
Coordinates 707428..707796 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSW75_RS03555 (705095) 705095..706627 + 1533 WP_001350525.1 protein YeeR -
JSW75_RS03560 (706624) 706624..707070 + 447 WP_000187523.1 RadC family protein -
JSW75_RS03565 (707133) 707133..707354 + 222 WP_000692323.1 DUF987 domain-containing protein -
JSW75_RS03570 (707428) 707428..707796 + 369 WP_001285584.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
JSW75_RS03575 (707885) 707885..708259 + 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
JSW75_RS03580 (708256) 708256..708450 + 195 WP_000988600.1 DUF5983 family protein -
JSW75_RS03585 (708496) 708496..708576 + 81 Protein_704 hypothetical protein -
JSW75_RS03590 (708865) 708865..708993 - 129 Protein_705 transposase domain-containing protein -
JSW75_RS03595 (709113) 709113..709247 + 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
JSW75_RS03600 (709348) 709348..709677 - 330 WP_000450409.1 DUF496 family protein -
JSW75_RS03605 (709849) 709849..710907 - 1059 WP_001200891.1 FUSC family protein -
JSW75_RS03610 (711105) 711105..711578 - 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
JSW75_RS03615 (711697) 711697..712863 - 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T190304 WP_000854814.1 NZ_CP069386:707885-708259 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T190304 NZ_CP091237:c2500898-2500794 [Enterococcus faecalis]
TTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATT
GCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13651.52 Da        Isoelectric Point: 5.9541

>AT190304 WP_001285584.1 NZ_CP069386:707428-707796 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT190304 NZ_CP091237:2500674-2500861 [Enterococcus faecalis]
TGTGCTATAATAAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCATGT
TAATTATTTAAAAATAACCGTGCTTGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGC
GCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
PDB 2H28
AlphaFold DB A0A1M2E8G6

References