Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 139604..140242 Replicon chromosome
Accession NZ_CP069386
Organism Escherichia coli strain XH1815

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag JSW75_RS00665 Protein ID WP_000813794.1
Coordinates 139604..139780 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JSW75_RS00670 Protein ID WP_001270286.1
Coordinates 139826..140242 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSW75_RS00645 (135223) 135223..136398 - 1176 WP_001236265.1 BenE family transporter YdcO -
JSW75_RS00650 (136490) 136490..137026 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
JSW75_RS00655 (137099) 137099..139060 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JSW75_RS00660 (139152) 139152..139382 - 231 WP_000494244.1 YncJ family protein -
JSW75_RS00665 (139604) 139604..139780 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JSW75_RS00670 (139826) 139826..140242 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JSW75_RS00675 (140321) 140321..141727 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
JSW75_RS00680 (141972) 141972..143117 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
JSW75_RS00685 (143135) 143135..144148 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
JSW75_RS00690 (144149) 144149..145090 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T190293 WP_000813794.1 NZ_CP069386:139604-139780 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T190293 NZ_CP091235:c300295-300200 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT190293 WP_001270286.1 NZ_CP069386:139826-140242 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT190293 NZ_CP091235:300100-300165 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATCAGTAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References