190285

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4274124..4274905 Replicon chromosome
Accession NZ_CP069381
Organism Salmonella enterica strain GSJ/2016-Sal-016

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A5I5SY00
Locus tag JSR10_RS20890 Protein ID WP_000626104.1
Coordinates 4274124..4274615 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag JSR10_RS20895 Protein ID WP_001110452.1
Coordinates 4274612..4274905 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSR10_RS20865 (4269264) 4269264..4271702 - 2439 WP_001014138.1 F4 (K88) fimbrial usher FaeD -
JSR10_RS20870 (4271712) 4271712..4272251 - 540 WP_000721295.1 type 1 fimbrial protein -
JSR10_RS20875 (4272286) 4272286..4272576 - 291 WP_000773468.1 PapB/FocB family fimbrial expression transcriptional regulator -
JSR10_RS20880 (4273159) 4273159..4273386 + 228 WP_001519955.1 hypothetical protein -
JSR10_RS20885 (4273661) 4273661..4273909 - 249 Protein_4083 IS481 family transposase -
JSR10_RS20890 (4274124) 4274124..4274615 - 492 WP_000626104.1 GNAT family N-acetyltransferase Toxin
JSR10_RS20895 (4274612) 4274612..4274905 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
JSR10_RS20900 (4275222) 4275222..4275443 + 222 WP_021001044.1 hypothetical protein -
JSR10_RS20905 (4275709) 4275709..4276584 + 876 WP_000921676.1 AraC family transcriptional regulator -
JSR10_RS20910 (4276581) 4276581..4276868 + 288 WP_001269916.1 transcriptional regulator RtsB -
JSR10_RS20915 (4276891) 4276891..4277106 + 216 WP_001595136.1 hypothetical protein -
JSR10_RS20920 (4277114) 4277114..4277383 + 270 WP_010989096.1 hypothetical protein -
JSR10_RS20925 (4277677) 4277677..4278582 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4262488..4277383 14895


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17631.42 Da        Isoelectric Point: 7.7297

>T190285 WP_000626104.1 NZ_CP069381:c4274615-4274124 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T190285 NZ_CP091231:c2716018-2715917 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT190285 WP_001110452.1 NZ_CP069381:c4274905-4274612 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT190285 NZ_CP091231:2715793-2715972 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5SY00

Antitoxin

Source ID Structure
AlphaFold DB A0A5I1DGA4

References