Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4135402..4135918 Replicon chromosome
Accession NZ_CP069381
Organism Salmonella enterica strain GSJ/2016-Sal-016

Toxin (Protein)


Gene name relE Uniprot ID A0A7U1KST9
Locus tag JSR10_RS20165 Protein ID WP_000220585.1
Coordinates 4135402..4135686 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U1KSR8
Locus tag JSR10_RS20170 Protein ID WP_000212721.1
Coordinates 4135676..4135918 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSR10_RS20150 (4130518) 4130518..4132170 + 1653 WP_000155065.1 alpha,alpha-phosphotrehalase -
JSR10_RS20155 (4132579) 4132579..4134717 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
JSR10_RS20160 (4134934) 4134934..4135398 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JSR10_RS20165 (4135402) 4135402..4135686 - 285 WP_000220585.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JSR10_RS20170 (4135676) 4135676..4135918 - 243 WP_000212721.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JSR10_RS20175 (4135996) 4135996..4137909 - 1914 WP_001212126.1 BglG family transcription antiterminator -
JSR10_RS20180 (4137926) 4137926..4138666 - 741 WP_000779253.1 KDGP aldolase family protein -
JSR10_RS20185 (4138663) 4138663..4139781 - 1119 WP_001139191.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
JSR10_RS20190 (4139765) 4139765..4140898 - 1134 WP_000459929.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-65)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10878.69 Da        Isoelectric Point: 9.8739

>T190284 WP_000220585.1 NZ_CP069381:c4135686-4135402 [Salmonella enterica]
MTYELEIDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T190284 NZ_CP091231:c2715585-2715484 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACAATAAAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8995.36 Da        Isoelectric Point: 5.0651

>AT190284 WP_000212721.1 NZ_CP069381:c4135918-4135676 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTFSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT190284 NZ_CP091231:2715365-2715539 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAA
TCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U1KST9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U1KSR8

References