Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3441955..3442575 Replicon chromosome
Accession NZ_CP069381
Organism Salmonella enterica strain GSJ/2016-Sal-016

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag JSR10_RS16955 Protein ID WP_001280991.1
Coordinates 3442357..3442575 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag JSR10_RS16950 Protein ID WP_000344807.1
Coordinates 3441955..3442329 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSR10_RS16940 (3437094) 3437094..3438287 + 1194 WP_001039200.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JSR10_RS16945 (3438310) 3438310..3441459 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
JSR10_RS16950 (3441955) 3441955..3442329 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
JSR10_RS16955 (3442357) 3442357..3442575 + 219 WP_001280991.1 HHA domain-containing protein Toxin
JSR10_RS16960 (3442754) 3442754..3443305 + 552 WP_001278792.1 maltose O-acetyltransferase -
JSR10_RS16965 (3443422) 3443422..3443892 + 471 WP_000136181.1 YlaC family protein -
JSR10_RS16970 (3443948) 3443948..3444088 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
JSR10_RS16975 (3444094) 3444094..3444354 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
JSR10_RS16980 (3444579) 3444579..3446129 + 1551 WP_000213139.1 EAL domain-containing protein -
JSR10_RS16990 (3446360) 3446360..3446749 + 390 WP_000961285.1 MGMT family protein -
JSR10_RS16995 (3446782) 3446782..3447351 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T190282 WP_001280991.1 NZ_CP069381:3442357-3442575 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T190282 NZ_CP091231:c1095180-1094758 [Enterococcus faecalis]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCAAATTTTGACGAATTAGTG
AAACTCTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCGAATCGCATGACAGAAGCACTTATTAGCCGTTTAAG
CGATCAAGGCTATAATTTAGTGATTGAAGGAACAGGACGAACAACAGACGTTCCCATTCAAACAGCCACAATGCTTCAAT
CTGGTTCTGTTGCAAAGTTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT190282 WP_000344807.1 NZ_CP069381:3441955-3442329 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT190282 NZ_CP091231:c1095454-1095182 [Enterococcus faecalis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGGGTATTAAA
TTATGTTTTGAATCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References