Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 842274..842899 Replicon chromosome
Accession NZ_CP069381
Organism Salmonella enterica strain GSJ/2016-Sal-016

Toxin (Protein)


Gene name vapC Uniprot ID A0A5U3PLM7
Locus tag JSR10_RS04060 Protein ID WP_023137617.1
Coordinates 842501..842899 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag JSR10_RS04055 Protein ID WP_000557549.1
Coordinates 842274..842501 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSR10_RS04025 (837318) 837318..838835 + 1518 WP_000003339.1 lysine--tRNA ligase -
JSR10_RS04030 (838911) 838911..839456 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
JSR10_RS04035 (839721) 839721..840479 + 759 WP_000244329.1 amidase activator ActS -
JSR10_RS04045 (840764) 840764..841570 - 807 WP_010989071.1 DUF1460 domain-containing protein -
JSR10_RS04050 (841845) 841845..842097 - 253 Protein_794 hypothetical protein -
JSR10_RS04055 (842274) 842274..842501 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
JSR10_RS04060 (842501) 842501..842899 + 399 WP_023137617.1 tRNA(fMet)-specific endonuclease VapC Toxin
JSR10_RS04065 (843707) 843707..844243 + 537 WP_001038502.1 STM3031 family outer membrane protein -
JSR10_RS04070 (844290) 844290..844922 + 633 WP_000835265.1 YfdX family protein -
JSR10_RS04075 (845641) 845641..846225 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 840764..850685 9921


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15009.37 Da        Isoelectric Point: 7.2155

>T190271 WP_023137617.1 NZ_CP069381:842501-842899 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSQMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T190271 NZ_CP091227:2312216-2312560 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTAGAAGAATATAATGTGGAGTTAGTTTTTACTACTTTGAACAAACGCGCATGTTTCGA
CCCTACCTACGGTATCATATTTGTAAATCAAAATTTAACACCATCAGAACAAGAAGAAGCAATATATCACGAGTTAAAGC
ATGTAAAAGACCATGTGGATATAATGGAATTGTATAAAATTCCTGCTTTTCGTTCTAAGATGGAATCCGAAGCAGAACAA
TATATGTTTAGAAGCTTAATCGAAAAATATGAAGGACAATACAATTATTCAAATGTTATAGCTCATTACAACTTAAAAAT
GGGACAAGAAATTTATTTGAAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT190271 WP_000557549.1 NZ_CP069381:842274-842501 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT190271 NZ_CP091227:2311865-2312197 [Enterococcus faecalis]
ATGAATACTTATGAAATAATAAAAGAGTTGACAAAAAGGAAGAAAATGTCTATTCGACAATTAGAAATTACTCTAGGTTA
CTCAAATGGATATTTTAGCAAGTGGAAAAAAGTTTCTCCAAACTCAGAAGGCCTACAAAAAGTTGCGGACTACTTCAATG
TATCGGTAGATTATCTATTGGGAAGAACTGATAATACTAAAGCAACTGATGAAAAAAATTCTGATGATTTAGATGATGTA
CTGGATAACGTCATGAGTTTTGACGGTGAACCGCTTGATGATCATGACAGAGAAGTTATCCGTGCATATTTAAAGGGTAG
ATTCGGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5U3PLM7

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References