Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 831386..832046 Replicon chromosome
Accession NZ_CP069381
Organism Salmonella enterica strain GSJ/2016-Sal-016

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag JSR10_RS03995 Protein ID WP_000244756.1
Coordinates 831633..832046 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag JSR10_RS03990 Protein ID WP_000351186.1
Coordinates 831386..831652 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSR10_RS03970 (827314) 827314..828747 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
JSR10_RS03975 (828906) 828906..829217 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
JSR10_RS03980 (829381) 829381..830040 + 660 WP_140902808.1 hemolysin III family protein -
JSR10_RS03985 (830156) 830156..831136 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
JSR10_RS03990 (831386) 831386..831652 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
JSR10_RS03995 (831633) 831633..832046 + 414 WP_000244756.1 protein YgfX Toxin
JSR10_RS04000 (832099) 832099..832620 - 522 WP_001055885.1 flavodoxin FldB -
JSR10_RS04005 (832733) 832733..833629 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
JSR10_RS04010 (833653) 833653..834366 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JSR10_RS04015 (834372) 834372..836105 + 1734 WP_023137618.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T190270 WP_000244756.1 NZ_CP069381:831633-832046 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T190270 NZ_CP091227:480832-480948 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT190270 WP_000351186.1 NZ_CP069381:831386-831652 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT190270 NZ_CP091227:c481064-480859 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References