Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 200668..201428 Replicon chromosome
Accession NZ_CP069381
Organism Salmonella enterica strain GSJ/2016-Sal-016

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag JSR10_RS00930 Protein ID WP_000533909.1
Coordinates 200943..201428 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag JSR10_RS00925 Protein ID WP_000965886.1
Coordinates 200668..200955 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSR10_RS00900 (195963) 195963..196265 + 303 WP_000605590.1 YsaB family lipoprotein -
JSR10_RS00905 (196404) 196404..197315 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
JSR10_RS00910 (197325) 197325..199394 + 2070 WP_023137713.1 glycine--tRNA ligase subunit beta -
JSR10_RS00915 (199576) 199576..199851 + 276 Protein_182 IS3 family transposase -
JSR10_RS00920 (200023) 200023..200490 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
JSR10_RS00925 (200668) 200668..200955 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
JSR10_RS00930 (200943) 200943..201428 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
JSR10_RS00935 (201800) 201800..202339 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
JSR10_RS00940 (202513) 202513..202725 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
JSR10_RS00945 (203014) 203014..203304 - 291 WP_000455790.1 HTH-type transcriptional regulator -
JSR10_RS00950 (203743) 203743..204453 + 711 WP_000190524.1 DUF3053 domain-containing protein -
JSR10_RS00955 (204503) 204503..205477 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
JSR10_RS00960 (205696) 205696..206358 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T190267 WP_000533909.1 NZ_CP069381:200943-201428 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T190267 NZ_CP091224:189065-189331 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT190267 WP_000965886.1 NZ_CP069381:200668-200955 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT190267 NZ_CP091224:188802-189065 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References