Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 36581..37193 Replicon plasmid unnamed2
Accession NZ_CP069372
Organism Neotabrizicola shimadae strain N10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JO391_RS21010 Protein ID WP_089258968.1
Coordinates 36798..37193 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JO391_RS21005 Protein ID WP_123130489.1
Coordinates 36581..36808 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JO391_RS20990 (JO391_20970) 32795..34006 - 1212 WP_220664811.1 plasmid replication protein RepC -
JO391_RS20995 (JO391_20975) 34189..35181 - 993 WP_089258974.1 plasmid partitioning protein RepB -
JO391_RS21000 (JO391_20980) 35181..36365 - 1185 WP_113901404.1 plasmid partitioning protein RepA -
JO391_RS21005 (JO391_20985) 36581..36808 + 228 WP_123130489.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JO391_RS21010 (JO391_20990) 36798..37193 + 396 WP_089258968.1 PIN domain-containing protein Toxin
JO391_RS21015 (JO391_20995) 37272..38156 - 885 WP_220664771.1 recombinase family protein -
JO391_RS21020 (JO391_21000) 38383..39453 + 1071 WP_220664772.1 hypothetical protein -
JO391_RS21025 (JO391_21005) 39465..40214 - 750 WP_220664773.1 CbtA family protein -
JO391_RS21030 (JO391_21010) 40233..40409 - 177 WP_084450957.1 CbtB domain-containing protein -
JO391_RS21035 (JO391_21015) 40686..41147 - 462 WP_051294570.1 Cu(I)-responsive transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..70477 70477


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

SpoVT-AbrB domain

(5-45)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 4.1653

>T190266 WP_089258968.1 NZ_CP069372:36798-37193 [Neotabrizicola shimadae]
MSAEFADTNVVLYLLDDGPKADRAELILGQGPRISVQVLNETLVNCRRKAGLSWEEAGTFLEGVRALCPVEDLTLQTHDV
GRALAERYGFSIYDAMIVASALVAGCTTLWSEDMQDGLLVEGQLRIVNPFA

Download         Length: 396 bp

>T190266 NZ_CP091221:1178258-1178524 [Enterococcus faecium]
ATGACCTACCGTTTAGAATTCACGCCTGAAATTCAGAAACAACTTCGTAAAATGGACAAGCATCAAGCGACGCTGATCGT
TCGATGGCTATATCAACATATTGATGGTATTGACGATCCGAGAAAATTCGGAAAAGGATTGACCGCTAATCGTTCAGGAC
AATGGCGTTATCGAATTGGCAAATATCGTGTGTTGGTAGAGATAGAAGATAATCAAATAGTTGTTATCGCTATTCAAGTG
GGACACCGAAAAAATGTCTATGATTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8531.80 Da        Isoelectric Point: 10.7157

>AT190266 WP_123130489.1 NZ_CP069372:36581-36808 [Neotabrizicola shimadae]
MQVAKWGNSLAVRLPAELVRELGLKEGDQIDLVKDDGQVRVRRLARADEVLTGLRRFRGKLPAAERLSREDAHER

Download         Length: 228 bp

>AT190266 NZ_CP091221:1178031-1178261 [Enterococcus faecium]
ATGGCTATGATTACGGTTCGTGTGAGTGATGCCGAAAAAGAATGGCTTTCTTATATGGCGGAATTTTATGGGATTACTTT
ATCTGAGCTTCTAAAAACCTATTCGATGGAACAACTAGAAGATGAATACGATCGTCAAACGGCTGAAATTGCCCATAAAC
ATTGGGTAGAAAGTGGAAAAACAACAGTATCCATGGAAGAAATCCTTCGTGAATTTGGAGGGTTGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References