Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1986378..1988134 Replicon chromosome
Accession NZ_CP069361
Organism Burkholderia pseudomallei strain VB29710

Toxin (Protein)


Gene name doc Uniprot ID C4APV8
Locus tag JQX71_RS26855 Protein ID WP_004195452.1
Coordinates 1987229..1988134 (-) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q63LW2
Locus tag JQX71_RS26850 Protein ID WP_004195450.1
Coordinates 1986378..1987232 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQX71_RS26830 1981594..1983084 - 1491 WP_004524006.1 aldehyde dehydrogenase -
JQX71_RS26835 1983110..1983925 - 816 WP_004195445.1 aspartate dehydrogenase -
JQX71_RS26840 1983918..1985591 - 1674 WP_024431007.1 thiamine pyrophosphate-binding protein -
JQX71_RS26845 1985584..1986381 - 798 WP_004540865.1 SDR family oxidoreductase -
JQX71_RS26850 1986378..1987232 - 855 WP_004195450.1 IclR family transcriptional regulator Antitoxin
JQX71_RS26855 1987229..1988134 - 906 WP_004195452.1 alpha/beta fold hydrolase Toxin
JQX71_RS26860 1988151..1988678 - 528 WP_004524001.1 cupin domain-containing protein -
JQX71_RS26865 1988717..1989487 - 771 WP_004524000.1 SDR family oxidoreductase -
JQX71_RS26870 1989484..1990551 - 1068 WP_004195457.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
JQX71_RS26875 1990586..1990897 - 312 WP_004184841.1 hypothetical protein -
JQX71_RS26880 1990899..1991216 - 318 WP_004184916.1 non-heme iron oxygenase ferredoxin subunit -
JQX71_RS26885 1991651..1992739 + 1089 WP_004184835.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(54-284)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 302 a.a.        Molecular weight: 30555.70 Da        Isoelectric Point: 8.7357

>T190263 WP_004195452.1 NZ_CP069361:c1988134-1987229 [Burkholderia pseudomallei]
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIQRCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP

Download         Length: 906 bp

>T190263 NZ_CP091213:476318-476659 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCAGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31152.56 Da        Isoelectric Point: 6.8932

>AT190263 WP_004195450.1 NZ_CP069361:c1987232-1986378 [Burkholderia pseudomallei]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp

>AT190263 NZ_CP091213:476088-476318 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N4FRK3

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4FRW8

References