Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1366669..1367231 Replicon plasmid pMVF16-2
Accession NZ_CP069356
Organism Microvirga sp. VF16

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JO965_RS39020 Protein ID WP_203446109.1
Coordinates 1366669..1367037 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JO965_RS39025 Protein ID WP_203446110.1
Coordinates 1367034..1367231 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JO965_RS39005 1362115..1363146 - 1032 WP_203446106.1 plasmid partitioning protein RepB -
JO965_RS39010 1363146..1364357 - 1212 WP_203446107.1 plasmid partitioning protein RepA -
JO965_RS39015 1365747..1366658 - 912 WP_203446108.1 recombinase family protein -
JO965_RS39020 1366669..1367037 - 369 WP_203446109.1 type II toxin-antitoxin system VapC family toxin Toxin
JO965_RS39025 1367034..1367231 - 198 WP_203446110.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JO965_RS39030 1367947..1368894 + 948 WP_203446761.1 DUF1612 domain-containing protein -
JO965_RS39035 1369045..1369971 + 927 WP_203446111.1 amidoligase family protein -
JO965_RS39040 1370119..1370649 - 531 WP_203446112.1 hypothetical protein -
JO965_RS39045 1370866..1371834 + 969 WP_203446113.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - adeG / htpB 1..1387944 1387944
- flank IS/Tn - - 1370866..1371834 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-46)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13215.24 Da        Isoelectric Point: 6.2241

>T190260 WP_203446109.1 NZ_CP069356:c1367037-1366669 [Microvirga sp. VF16]
VIIVDTSVWIDHLKSGDAVLADLLGAGRILAHSFVTGELALGSLRQRGAVLESLRDLPQAIVARDDEVMMLIEREQLYGR
GIGFVDAHLLAAARLTSGSLVWTRDRRLRQAATQLGLSAELS

Download         Length: 369 bp

>T190260 NZ_CP091210:181133-181399 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7179.30 Da        Isoelectric Point: 10.5887

>AT190260 WP_203446110.1 NZ_CP069356:c1367231-1367034 [Microvirga sp. VF16]
VRTTIAIDDELVAKAQAFTGLQEKSALVREALKALIERESARRLARLGGTEPDLKPIPRRQADPK

Download         Length: 198 bp

>AT190260 NZ_CP091210:180870-181133 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References