Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 277820..278455 Replicon plasmid pMVF16-1
Accession NZ_CP069355
Organism Microvirga sp. VF16

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JO965_RS26775 Protein ID WP_203445135.1
Coordinates 278204..278455 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JO965_RS26770 Protein ID WP_203445134.1
Coordinates 277820..278194 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JO965_RS26735 272837..273052 + 216 Protein_257 tyrosine-type recombinase/integrase -
JO965_RS26740 273092..273736 - 645 WP_203445131.1 DUF1738 domain-containing protein -
JO965_RS26745 274235..274617 + 383 Protein_259 peptidase S24 -
JO965_RS26750 274729..274926 + 198 WP_203445132.1 hypothetical protein -
JO965_RS26755 274919..276680 + 1762 Protein_261 recombinase family protein -
JO965_RS26760 276622..277415 + 794 Protein_262 DUF4113 domain-containing protein -
JO965_RS26765 277402..277665 - 264 WP_203445133.1 hypothetical protein -
JO965_RS26770 277820..278194 - 375 WP_203445134.1 helix-turn-helix transcriptional regulator Antitoxin
JO965_RS26775 278204..278455 - 252 WP_203445135.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JO965_RS26780 278643..279863 + 1221 WP_203445136.1 IS4 family transposase -
JO965_RS26785 279856..280215 + 360 WP_203445137.1 hypothetical protein -
JO965_RS26790 280293..281630 - 1338 WP_203445138.1 hypothetical protein -
JO965_RS26795 281525..282262 - 738 WP_203445139.1 ParB/RepB/Spo0J family partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..1403018 1403018


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-79)

Antitoxin

Cro/C1-type helix-turn-helix domain

(69-123)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9108.52 Da        Isoelectric Point: 10.5112

>T190257 WP_203445135.1 NZ_CP069355:c278455-278204 [Microvirga sp. VF16]
MKKIAYSKSALKTLRRIPANVSATIRGKIEQYASDPASLSANVTKLQGREGYRLRVGDWRVIFDEDGTVLAILEIGPRGG
IYG

Download         Length: 252 bp

>T190257 NZ_CP091206:c999971-999705 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13524.14 Da        Isoelectric Point: 4.3402

>AT190257 WP_203445134.1 NZ_CP069355:c278194-277820 [Microvirga sp. VF16]
MNKPDIITTPSGDRLAIMPLADYESLVASAEQSADVRAYDEAKRRIASGEDELVPSEFANRILDGESPVRVWREYRGMSA
KDLAAKTGLSPAYISQIETGDRDGSFETMKKIAQALSVSLDDLA

Download         Length: 375 bp

>AT190257 NZ_CP091206:c1000234-999971 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References