Detailed information of TA system TA190255

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4011882..4012513
• Replicon: chromosome
• Accession: NZ_CP069354
• Organism: Microvirga sp. VF16

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JO965_RS18745
• Protein ID: WP_203440523.1
• Coordinates: 4011882..4012295 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: -
• Locus tag: JO965_RS18750
• Protein ID: WP_203440524.1
• Coordinates: 4012295..4012513 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JO965_RS18720	4007129..4008460	-	1332	WP_203440518.1	NCS2 family nucleobase:cation symporter	-
JO965_RS18725	4008634..4009653	+	1020	WP_203440519.1	enterochelin esterase	-
JO965_RS18730	4009663..4010610	-	948	WP_203440520.1	NAD(P)/FAD-dependent oxidoreductase	-
JO965_RS18735	4010899..4011414	+	516	WP_203440521.1	hypothetical protein	-
JO965_RS18740	4011427..4011804	+	378	WP_203440522.1	HNH endonuclease	-
JO965_RS18745	4011882..4012295	-	414	WP_203440523.1	type II toxin-antitoxin system VapC family toxin	Toxin
JO965_RS18750	4012295..4012513	-	219	WP_203440524.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
JO965_RS18755	4012590..4013072	-	483	WP_203440525.1	hypothetical protein	-
JO965_RS18760	4013069..4013731	-	663	WP_203440526.1	hypothetical protein	-
JO965_RS18765	4014468..4014695	-	228	WP_203440527.1	hypothetical protein	-
JO965_RS18770	4015022..4015195	-	174	WP_203440528.1	hypothetical protein	-
JO965_RS18775	4015718..4016209	+	492	WP_203440529.1	peptidoglycan-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-128)

Antitoxin

• SpoVT-AbrB domain (7-43)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15309.64 Da
• Isoelectric Point: 5.1955

>T190255 WP_203440523.1 NZ_CP069354:c4012295-4011882 [Microvirga sp. VF16]
MPEPRYLLDTNICIYIRRERPPSVLDRFKALNPGSTVISVITYGELVYGARKSQDSDKAMMILDELTELIPVVPMATDVA
DTYGLIRSDLSARGALIGNNDLWIAAHAMSLNLTLVTNNEKEFQRVGGLTLENWAKR

Nucleotide

• Length: 414 bp

>T190255 NZ_CP091205:c24530-23667 [Enterococcus gallinarum]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTATATAACAGAGAAGGAGTAAAACTCTATTCAA
GTTTGGAAACACCTTCTATTAGTCCAAAAGAAACCTTAGAAAAAGAATTGAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTAGAACGAATAGAGCAAAAAATGGTTCTAAATAAACACCAAGAGACACCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGTATTTAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8329.55 Da
• Isoelectric Point: 7.9939

>AT190255 WP_203440524.1 NZ_CP069354:c4012513-4012295 [Microvirga sp. VF16]
MAFAKVFRSGNSQAVRLPKQFRLTSDEVEIFRRGDEIVLREKPRSLARAFELLCDLPEVERDDAPPQERKGL

Nucleotide

• Length: 219 bp

>AT190255 NZ_CP091205:c24804-24532 [Enterococcus gallinarum]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA