Detailed information of TA system TA190249

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3072915..3073524
• Replicon: chromosome
• Accession: NZ_CP069352
• Organism: Pseudomonas granadensis isolate CT364

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JN757_RS13460
• Protein ID: WP_203421985.1
• Coordinates: 3073153..3073524 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JN757_RS13455
• Protein ID: WP_203421984.1
• Coordinates: 3072915..3073163 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN757_RS13435	3068240..3068980	+	741	WP_203421980.1	VWA domain-containing protein	-
JN757_RS13440	3069297..3070856	+	1560	WP_203421981.1	TerC family protein	-
JN757_RS13445	3070999..3072075	-	1077	WP_203421982.1	GGDEF domain-containing protein	-
JN757_RS13450	3072234..3072668	-	435	WP_203421983.1	thioredoxin family protein	-
JN757_RS13455	3072915..3073163	+	249	WP_203421984.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JN757_RS13460	3073153..3073524	+	372	WP_203421985.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JN757_RS13465	3073708..3074556	+	849	WP_203421986.1	transporter substrate-binding domain-containing protein	-
JN757_RS13470	3074608..3075270	+	663	WP_024012746.1	amino acid ABC transporter permease	-
JN757_RS13475	3075280..3075942	+	663	WP_203421987.1	amino acid ABC transporter permease	-
JN757_RS13480	3075939..3076730	+	792	WP_203421988.1	amino acid ABC transporter ATP-binding protein	-
JN757_RS13485	3076759..3077148	+	390	WP_090283235.1	RidA family protein	-
JN757_RS13490	3077305..3078069	+	765	WP_203422078.1	IclR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13857.43 Da
• Isoelectric Point: 10.4255

>T190249 WP_203421985.1 NZ_CP069352:3073153-3073524 [Pseudomonas granadensis]
MTYELEFSEKAWKEWMKLGAVMKEQFKKKLAERLLNPHIPSARLKDLGNAYKIKLQSAGYRLVYRVSNEVLIVTVIAIGK
RAGAMYMRLRLDADCNFGSLLNAPKSPTPIPFGNLIPACGSVR

Nucleotide

• Length: 372 bp

>T190249 NZ_CP091198:1340115-1340753 [Enterococcus faecalis]
ATGATACTAAATAAGAAAAAATTATATTTCGAAACACAGGCATTTACTGACAAACTTATAAATGAAATTTCAATCAATAT
GTCTAAAAGAAAAGAACTCATCAATTGTTATGATATTGAAGCCTACGTAAAAGAAACCGAAAACATTGATTTTTTTGATT
ATCCATTCAAAAAACAATCTAAAAAATTAATCTGGGGATCAGTAACAAAAATTGGTGATGTAACTATGGTAGCGACTGCC
CAACACTTGAAAATAGAAATTAAAAATTTTACGAAAATGCACGAAATAATTCATCATTATTTTGACTATACGACAGATAT
GCCTAACAATGAAAAATCATTTGATACACTACTTATAAAAAAGGGCTATCTTCCTGAAGATTATCCTAAAGAATTCAGAG
CAAATAAGGGTGCCGGAATGTTACTTATTAATAAAAAAGCCTTAAAGTATGCATTTAGTACTTATGATGATCTTGAAAAA
ATGGCTAGTTTTTTCAACGTAAACGATATAGTTCTCAAGATAAGAATTCTTGACGAATTAATCTATTCCCACAACTTATC
TTATAAACAAGCCAATCTTATTTATAATAGTTACTATTTTCAACAACAAACACAACTTAAAGAGATTTTACTCAAATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8957.34 Da
• Isoelectric Point: 4.7163

>AT190249 WP_203421984.1 NZ_CP069352:3072915-3073163 [Pseudomonas granadensis]
MAHIVLSNVVASISELKKDPMGTVAAGGGHSVAILNRNQPAFYCVPAKEYEAMMTRLDDLELIALCKERENDPTIRVSID
DL

Nucleotide

• Length: 249 bp

>AT190249 NZ_CP091198:1339736-1340104 [Enterococcus faecalis]
ATGAAAACTTACGAAAAGATAAAACAATTAAGAGAAAATAGAGAAATCACTCAAAAAGAAATTTCAAACGCACTAGACAT
TAATGTTAGTGTATATAATAAAATAGAACTTGGAATACGTCCATTAAGAGAAGAAGAACTTACTGCTATTGCTGATTTTT
TTAATGTTTCAATTGATTATTTAACAGGACGCACTGATAACCCTACAACACCTTCAAATAATCAAAAAGAAGCTGGACAA
AATATTATTTCACATTTCAGATTAAACACTAATGATTTAAGTTCTGATGACATAGAAGAATTAGAAAAAGAATTGATTGA
TTTTCAAGAATTTCTTATAAAACGAGCAAAAGAAAGAAAAAAAGAGTGA