Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 141678..143302 Replicon chromosome
Accession NZ_CP069352
Organism Pseudomonas granadensis isolate CT364

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JN757_RS00665 Protein ID WP_203420067.1
Coordinates 141953..143302 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JN757_RS00660 Protein ID WP_090287690.1
Coordinates 141678..141956 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN757_RS00630 137097..137720 + 624 WP_203420061.1 FMN-binding negative transcriptional regulator -
JN757_RS00635 137731..138177 + 447 WP_203420062.1 GNAT family N-acetyltransferase -
JN757_RS00640 138190..138861 + 672 WP_203420063.1 GNAT family N-acetyltransferase -
JN757_RS00645 138978..139880 - 903 WP_203420064.1 homocysteine S-methyltransferase family protein -
JN757_RS00650 139995..140816 + 822 WP_203420065.1 ABC transporter substrate-binding protein -
JN757_RS00655 140813..141649 + 837 WP_203420066.1 amino acid ABC transporter permease -
JN757_RS00660 141678..141956 - 279 WP_090287690.1 helix-turn-helix domain-containing protein Antitoxin
JN757_RS00665 141953..143302 - 1350 WP_203420067.1 HipA domain-containing protein Toxin
JN757_RS00670 143533..146487 + 2955 WP_203420068.1 autotransporter domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-367)

Antitoxin

Cro/C1-type helix-turn-helix domain

(27-80)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 49917.43 Da        Isoelectric Point: 5.0465

>T190245 WP_203420067.1 NZ_CP069352:c143302-141953 [Pseudomonas granadensis]
MYNLTLQIFTAGIWHDAMVLSFDDPEKGFASRCSFGYETDYLAENIEAIGSPFSKAVSALYPLDWDGRRSETPAFVHDIA
PAGAARRFLLARLGQEKPADISADLYLLGRSTPAPIGNMRIKESAAAVDERKPIGFKREDVIHRDQRFLEYAYELGAAIG
GATGAGGEAPKLLLVENHAGLLYPDAVLSDEDVRQHWFVKFARNRGGLTDQDILRSEFHYYKALQTLGIDTIAEDGLALE
EANKPSLWMHRFDRSVQNGEVSRFAVESIYSLAQVTTPGSAMNHLEVIRLLAGLWRTAGQTSQIPDLVADYLCRDLINKI
LGNSDNHGRNTAIIREADAFRLAPIYDLAPMVMDDEGVTRTTKWPRELERAGDIDWRGVCRALVDIAEPGDPTAVSDESM
LFERLRQEAQRLSALPDILADSGLPARTMNHPGVHLKNLQQRLNDWGLK

Download         Length: 1350 bp

>T190245 NZ_CP091198:1173871-1173975 [Enterococcus faecalis]
TTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATT
GCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10254.91 Da        Isoelectric Point: 10.9503

>AT190245 WP_090287690.1 NZ_CP069352:c141956-141678 [Pseudomonas granadensis]
MSLSVAERTALIESIQQALAQGTLDIGEAVRRLRVEVTGLHQTQFARMCKISVRTLVHIEHGEGNQTLKSLNAVFRPFGM
KMGVVRIHRDNS

Download         Length: 279 bp

>AT190245 NZ_CP091198:c1173731-1173577 [Enterococcus faecalis]
TTTTTAGGTAAGTGTGCTATAATAGCAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCGGTTTAAGA
CGGTGACCTTTTGGATTATTTAAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCTTCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References