Detailed information of TA system TA190244

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParE-CopA/ParE-RHH
• Location: 2568016..2568581
• Replicon: chromosome
• Accession: NZ_CP069350
• Organism: Shewanella sp. LZH-2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: JM642_RS11420
• Protein ID: WP_076500099.1
• Coordinates: 2568288..2568581 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: copA
• Uniprot ID: -
• Locus tag: JM642_RS11415
• Protein ID: WP_115014944.1
• Coordinates: 2568016..2568300 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JM642_RS11375	2563235..2563456	-	222	WP_203431817.1	AlpA family transcriptional regulator	-
JM642_RS11380	2563624..2564085	+	462	WP_203433795.1	DNA repair protein RadC	-
JM642_RS11385	2564121..2564483	+	363	WP_071939741.1	hypothetical protein	-
JM642_RS11390	2564623..2564979	+	357	WP_203431818.1	type IV toxin-antitoxin system YeeU family antitoxin	-
JM642_RS11395	2565232..2565645	+	414	WP_203431819.1	DUF2787 domain-containing protein	-
JM642_RS11400	2565839..2566246	+	408	WP_203431820.1	DUF2787 domain-containing protein	-
JM642_RS11405	2566355..2566921	+	567	WP_203431821.1	site-specific integrase	-
JM642_RS11410	2567009..2567731	+	723	WP_203431822.1	lecithin retinol acyltransferase family protein	-
JM642_RS11415	2568016..2568300	+	285	WP_115014944.1	CopG family ribbon-helix-helix protein	Antitoxin
JM642_RS11420	2568288..2568581	+	294	WP_076500099.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JM642_RS11425	2568724..2569401	-	678	WP_203431823.1	inovirus Gp2 family protein	-
JM642_RS11430	2569604..2570167	-	564	WP_203431824.1	DUF3987 domain-containing protein	-
JM642_RS11435	2570168..2570737	-	570	WP_203431825.1	DUF3987 domain-containing protein	-
JM642_RS11440	2570682..2571140	-	459	WP_203431826.1	DUF3987 domain-containing protein	-
JM642_RS11445	2571198..2571410	-	213	WP_203431827.1	AlpA family phage regulatory protein	-
JM642_RS11450	2571550..2572695	-	1146	WP_203431828.1	hypothetical protein	-
JM642_RS11455	2573089..2573253	-	165	Protein_2191	DUF86 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-44)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11153.71 Da
• Isoelectric Point: 5.8404

>T190244 WP_076500099.1 NZ_CP069350:2568288-2568581 [Shewanella sp. LZH-2]
MPQIIFTATALRDLERLREFLRTKNPPAAQRAASAIINTIRKLESYPDIGRPIDDNDFSFRELLIDFGDTGYLAMYQYDG
GERLTVLCIRHQKEAGY

Nucleotide

• Length: 294 bp

>T190244 NZ_CP091198:c1000761-1000660 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAACCCTTGTTGCGTTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10941.26 Da
• Isoelectric Point: 6.3342

>AT190244 WP_115014944.1 NZ_CP069350:2568016-2568300 [Shewanella sp. LZH-2]
MSTIKPVSVKLDADIKARVEHLAETRKRSSHWMMREAIREYVEREEKREALQQEALRAWEEHQTSGLHVTGDEVVSWLES
WGSENEKAAPSCHK

Nucleotide

• Length: 285 bp

>AT190244 NZ_CP091198:1000536-1000723 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAACGCAACAAGGGTTGCA