Detailed information of TA system TA190242

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4537000..4538258
• Replicon: chromosome
• Accession: NZ_CP069337
• Organism: Pseudomonas aeruginosa strain E04

Toxin (Protein)

• Gene name: -
• Uniprot ID: V6AJ34
• Locus tag: JQ456_RS21020
• Protein ID: WP_003086331.1
• Coordinates: 4537000..4537755 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: JQ456_RS21025
• Protein ID: WP_003086329.1
• Coordinates: 4537890..4538258 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQ456_RS21010 (JQ456_21005)	4532170..4534713	+	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-
JQ456_RS21015 (JQ456_21010)	4534868..4536229	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
JQ456_RS21020 (JQ456_21015)	4537000..4537755	-	756	WP_003086331.1	RES family NAD+ phosphorylase	Toxin
JQ456_RS21025 (JQ456_21020)	4537890..4538258	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
JQ456_RS21030 (JQ456_21025)	4538331..4539617	-	1287	WP_070698512.1	FAD-binding oxidoreductase	-
JQ456_RS21035 (JQ456_21030)	4539673..4541166	-	1494	WP_003086325.1	aldehyde dehydrogenase family protein	-
JQ456_RS21040 (JQ456_21035)	4541341..4541817	+	477	WP_019372052.1	elongation factor GreAB	-
JQ456_RS21045 (JQ456_21040)	4541820..4542095	-	276	WP_010792073.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28236.34 Da
• Isoelectric Point: 7.7294

>T190242 WP_003086331.1 NZ_CP069337:c4537755-4537000 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T190242 NZ_CP091198:851631-851975 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATAATGTGGAGTTAGTTTTTACTACATTACACAAAAAGGCTTGTTTCGA
ACCAAAGTATGGTGTAATTTTCATTAATCAAGATTTATCTACTGCAGAACAAGAAGAAGCTATTTATCATGAATTTAAGC
ACGTGAAAGATCATGCTGATTTGATGGCACTATACAACATTCCTATTTTCAGATCAAAAATGGAAGCAGAAGCTGAACAA
TATATGCTCGAATGTTTAATCGAAAAGAACGGTGGTCAATTTAACTATTCTAATGTAATTACACATTATAATTTAAAGAT
GGGCCAAGAAATTTACTTAAAATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT190242 WP_003086329.1 NZ_CP069337:c4538258-4537890 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT190242 NZ_CP091198:851280-851612 [Enterococcus faecalis]
ATGACAGCATTTGATAGAATAAAAAAAATTACAGACCGTAGAGGTATTTCCATTAATGAGTTAGAAAATCGAGTTGGAAT
TAGTCAAAATGTATTATATGGATGGAAGAAAAAAACTCCTGGCGGTGAAAATTTGACTAAAGTTGCTAAATATTTAAATA
TTTCCACTGATTATATTTTAGGAATAGTTGATAATCCAGAACCTTTTGTCGAAAAAAAAACTGATGATTTGGATGAAGTT
TTAGACAATGTGATGAGTTTTGACGGTGAACCACTTGATGATCATGACAGAGAAGTTATACGTGCATATTTAAAGGGTAG
ATTTGGGAAATAA

Structures

Toxin

• AlphaFold DB: V6AJ34

Antitoxin

• AlphaFold DB: V6AJU7